Estimation of the cutoff value of vitamin D: the Dong-gu study

Journal of Physiological Anthropology

Min-Ho Shin⁴  Hye-Rim Song¹  So-Yeon Ryu⁶  Kyeong-Soo Park⁷  Seul-Ki Jeong⁸  Hae-Sung Nam³  Young-Hoon Lee⁵  Jung-Ae Rhee⁴  Jin-Su Choi⁴  Sun-Seog Kweon²  Seong-Woo Choi⁶ 

[1] Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Jeollanamdo 519-809, Republic of Korea;Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Jeollanamdo 519-809, Republic of Korea;Department of Preventive Medicine, Chungnam National University Medical School, Munhwa 1(il)-dong,, Jung-gu, Republic of Korea;Department of Preventive Medicine, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea;Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Jeollabukdo 570-711, Republic of Korea;Department of Preventive Medicine, Chosun University Medical School, Gwangju 501-759, Republic of Korea;Department of Preventive Medicine, Seonam University College of Medicine, Jeollabukdo 590-711, Republic of Korea;Department of Neurology & Research Institute of Clinical Medicine, Biomedical Institute of Chonbuk National University Hospital, Chonbuk National University, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Republic of Korea

关键词: Cutoff value;    25-hydroxyvitamin D;    Parathyroid hormone;    Vitamin D;   

Others  :  1139856
DOI  :  10.1186/s40101-015-0048-4

 received in 2014-08-18, accepted in 2015-02-13,  发布年份 2015

【 摘 要 】

Background

Vitamin D plays an essential role in bone health and growth, but the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration is not known. This study was performed to investigate the optimal 25(OH)D concentration in regard to parathyroid hormone (PTH) concentration in the Korean general population aged 50 years or older.

Findings

The study population consisted of 8,857 subjects (3,545 men and 5,312 women) who participated in the baseline survey of the Dong-gu study, conducted in Korea between 2007 and 2010. Serum 25(OH)D and PTH concentrations were measured by chemiluminescent microparticle immunoassay. The optimal 25(OH)D concentration was estimated by using nonlinear regression model. Our data show that PTH concentration reached a theoretical plateau at 38.2 pg/ml and corresponding 25(OH)D concentration was 21.1 ng/ml in men and PTH concentration at 42.9 pg/ml and 25(OH)D concentration at 13.8 ng/ml in women.

Conclusions

These results indicate that, for Korean general population aged 50 years or older, the optimal 25(OH)D concentration is 21.1 ng/ml in men and 13.8 ng/ml in women.

【 授权许可】

   
2015 Choi et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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