MRI for discriminating metastatic ovarian tumors from primary epithelial ovarian cancers

Journal of Ovarian Research

Guixiang Zhang¹  Zaixian Zhang¹  Jia Yang¹  Yanhong Xu¹ 

[1] Department of Radiology, Shanghai First People’s Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Shanghai 200080, People’s Republic of China

关键词: Magnetic resonance imaging;    Metastatic;    Primary epithelial ovarian cancer;    Ovary;   

Others  :  1224694
DOI  :  10.1186/s13048-015-0188-5

 received in 2015-01-05, accepted in 2015-08-25,  发布年份 2015

【 摘 要 】

Aims

To find specific magnetic resonance imaging (MRI) features to differentiate metastatic ovarian tumors from primary epithelial ovarian cancers.

Methods

Eleven cases with metastatic ovarian tumors and 26 cases with primary malignant epithelial ovarian cancers were retrospectively studied. All features such as patient characteristics, MRI findings and biomarkers were evaluated. The differences including laterality, configuration, uniformity of locules, diffusion weighted imaging (DWI) signal of solid components and enhancement of solid portions between metastatic ovarian tumors and primary epithelial ovarian cancers were compared by Fisher’s exact test. Median age of patients, the maximum diameter of lesions and biomarkers were compared by the Mann-Whitney test.

Results

Patients with metastatic ovarian tumors were younger than patients with primary epithelial ovarian cancers in the median age (P = 0.015). Patients with bilateral tumors in metastatic ovarian tumors were more than those of primary epithelial ovarian cancers (P = 0.032). The maximum diameter of lesions in metastatic ovarian tumors was smaller than that of primary epithelial ovarian cancers (P = 0.005). The locules in metastatic ovarian tumors were more uniform than those of primary epithelial ovarian cancers (P = 0.024). The enhancement of solid portions in metastatic ovarian tumors showed more moderate than that of primary epithelial ovarian cancers (P = 0.037). There was no statistically significant difference between the two groups in configuration, DWI signal of solid components and ascites. Biomarkers such as CA125 and human epididymis protein 4 (HE4) in metastatic ovarian tumors showed less elevated than that of primary epithelial ovarian cancers.

Conclusions

Significant differences between metastatic ovarian tumors and primary epithelial ovarian cancers were found in the median age of patients, laterality, the maximum diameter of lesions, uniformity of locules, enhancement patterns of solid portions and biomarkers. Metastatic ovarian tumors usually presented in the younger patients, smaller-sized, more bilateral lesions, more uniform of locules, more moderate enhancement of solid portions, and less elevated levels of CA125 and HE4 than those of primary epithelial ovarian cancers.

【 授权许可】

   
2015 Xu et al.

【 图 表 】

Fig. 1.

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