Extracellular matrix production in vitro in cartilage tissue engineering

Journal of Translational Medicine

Daping Wang¹  Jianyi Xiong¹  Weimin Zhu¹  Li Duan¹  Jie-Lin Chen¹ 

[1] Department of Orthopedics, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China

关键词: Collagen type II;    Extracellular matrix;    Tissue engineering;    Cartilage;   

Others  :  815146
DOI  :  10.1186/1479-5876-12-88

 received in 2013-12-04, accepted in 2014-03-31,  发布年份 2014

【 摘 要 】

Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage.

【 授权许可】

   
2014 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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