Joint modelling of repeated measurements and event time: Application to performance traits and survival of lambs bred in sub-humid tropics

Genetics Selection Evolution

Paul Janssen¹  Didier Renard¹  John Rowlands²  Tomasz Burzykowski¹  Rosemary Nguti² 

[1] Center for Statistics, Limburgs Universitair Centrum, Diepenbeek, Belgium;International Livestock Research Institute, Nairobi, Kenya

关键词: helminthiasis;    sheep;    joint modelling;    time-to-event;    repeated measurements;   

Others  :  1094248
DOI  :  10.1186/1297-9686-37-3-175

 received in 2004-03-09, accepted in 2004-10-07,  发布年份 2005

【 摘 要 】

We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis. The available data include information on time to death and repeated measurements of body weight, packed cell volume (PCV) and faecal egg count (FEC) of the animals. In the paper, we consider joint modelling of the survival time and the repeated measurements. Such an approach allows to account for the possible association between the survival and repeated measurement processes. The advantages and limitations of the joint modelling are discussed and illustrated using the Diani Estate study data.

【 授权许可】

   
2005 INRA, EDP Sciences