International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs

BMC Veterinary Research

Holger A. Volk²  Rowena M.A. Packer²  Simon Platt⁸  Edward E. Patterson³  Akos Pakozdy⁶  Sofie F.M. Bhatti⁹  Clare Rusbridge⁷  Mette Berendt⁴  Luisa DeRisio⁵  Paul J.J. Mandigers¹  Andrea Fischer^1,10  Velia-Isabel Hülsmeyer^1,10 

[1] Department of Clinical Sciences of Companion Animals, Utrecht University, Yalelaan 108, 3583 CM, Utrecht, The Netherlands;Department of Clinical Science and Services, Royal Veterinary College, Hatfield AL9 7TA, Hertfordshire, UK;University of Minnesota College of Veterinary Medicine, D426 Veterinary Medical Center, 1352 Boyd Avenue, St. Paul 55108, MN, USA;Department of Veterinary and Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark;Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU, United Kingdom;Clinical Unit of Internal Medicine Small Animals, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria;School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7TE, United Kingdom;College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens 30602, GA, USA;Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium;Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Veterinärstr. 13, Munich, 80539, Germany

关键词: Epileptic seizure;    Epilepsy prevalence;    Breed;    Dog;    Idiopathic epilepsy;   

Others  :  1224284
DOI  :  10.1186/s12917-015-0463-0

 received in 2015-06-04, accepted in 2015-06-29,  发布年份 2015

【 摘 要 】

Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted.

【 授权许可】

   
2015 Hülsmeyer et al.

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