Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord

Journal of Biomedical Science

Kambiz Hassanzadeh⁵  Mehran Mesgari³  Arash Khorrami⁴  Bahman Yousefi⁶  Saeed Ghanbarzadeh¹  Hamed Ghavimi²  Mohammad Charkhpour⁴ 

[1] Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;Cellular and Molecular Research Center and Department of Physiology and Pharmacology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

关键词: PPAR-γ;    GW-9662;    Neuroinflammation;    Morphine;    Pioglitazone;   

Others  :  1232320
DOI  :  10.1186/s12929-015-0187-2

 received in 2015-02-19, accepted in 2015-09-10,  发布年份 2015

【 摘 要 】

Background

Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated receptor gamma (PPAR-γ) agonist, on the morphine-induced neuroinflammation in the lumbar region of the male Wistar rat spinal cord.

Results

Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Administration of the GW-9662 antagonized the above mentioned effects of the pioglitazone.

Conclusions

It is concluded that oral administration of the pioglitazone attenuates morphine-induced tolerance and the neuroinflammation in the lumbar region of the rat spinal cord. This action of the pioglitazone may be, at least in part, due to an interaction with the spinal pro-inflammatory cytokine expression and the nuclear factor-kappa B activity.

【 授权许可】

   
2015 Charkhpour et al.

【 图 表 】

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