Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks

EvoDevo

Veronica F Hinman¹  Alys M Cheatle Jarvela¹ 

[1] Department of Biological Sciences, Carnegie Mellon University, 4400 5th Ave, Pittsburgh, PA 15213, USA

关键词: Novelty;    Development;    Gene regulatory network;    Transcription factor;   

Others  :  1121304
DOI  :  10.1186/2041-9139-6-3

 received in 2014-11-05, accepted in 2014-12-18,  发布年份 2015

【 摘 要 】

The form that an animal takes during development is directed by gene regulatory networks (GRNs). Developmental GRNs interpret maternally deposited molecules and externally supplied signals to direct cell-fate decisions, which ultimately leads to the arrangements of organs and tissues in the organism. Genetically encoded modifications to these networks have generated the wide range of metazoan diversity that exists today. Most studies of GRN evolution focus on changes to cis-regulatory DNA, and it was historically theorized that changes to the transcription factors that bind to these cis-regulatory modules (CRMs) contribute to this process only rarely. A growing body of evidence suggests that changes to the coding regions of transcription factors play a much larger role in the evolution of developmental gene regulatory networks than originally imagined. Just as cis-regulatory changes make use of modular binding site composition and tissue-specific modules to avoid pleiotropy, transcription factor coding regions also predominantly evolve in ways that limit the context of functional effects. Here, we review the recent works that have led to this unexpected change in the field of Evolution and Development (Evo-Devo) and consider the implications these studies have had on our understanding of the evolution of developmental processes.

【 授权许可】

   
2015 Cheatle Jarvela and Hinman; licensee BioMed Central.

【 图 表 】

Figure 1.

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