Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report

Chinese Medicine

David Cohen⁴  Marie Vidailhet⁵  Zahir Amoura³  Adrien Didelot²  Olivier Bonnot⁴  Philippe Maksud¹  Delphine Montefiore⁶  Nathalie Costedoat-Chalumeau³  Donata Marra³  Martine Barbeau⁴  Isabelle An-Gourfinkel⁵  Karine Ronen⁴  Angèle Consoli⁴ 

[1] Department of Nuclear Medicine, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France;Reference center of paraneoplastic neurological syndrome diagnosis and treatment, Hôpital Pierre Wertheimer, 59, bld Pinel, 69 003 Lyon;Department of Internal Medicine, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France;Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France;Department of Neurology, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France;Department of Adult Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75013, Paris, France

关键词: Malignant catatonia;    Adolescence;    Anti-NMDA-Receptor encephalitis;   

Others  :  791600
DOI  :  10.1186/1753-2000-5-15

 received in 2011-01-21, accepted in 2011-05-13,  发布年份 2011

【 摘 要 】

Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation.

【 授权许可】

   
2011 Consoli et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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