Is switching to an oral antibiotic regimen safe after 2 weeks of intravenous treatment for primary bacterial vertebral osteomyelitis?

BMC Infectious Diseases

Manuel Battegay³  Andreas F Widmer³  Stefan Schären⁴  Maja Weisser³  Reno Frei²  Marko Kolbe¹  Luigia Elzi³  Baharak Babouee Flury³ 

[1] Medical Faculty, University of Basel, Basel, Switzerland;Division of Clinical Microbiology, University Hospital Basel, Basel, Switzerland;Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Petersgraben 4, Basel 4031, Switzerland;Department of Orthopedic Surgery, University Hospital of University Basel, Basel, Switzerland

关键词: Antibiotic management;    Switch to oral therapy;    Vertebral osteomyelitis;   

Others  :  1133976
DOI  :  10.1186/1471-2334-14-226

 received in 2013-08-22, accepted in 2014-04-17,  发布年份 2014

【 摘 要 】

Background

Vertebral osteomyelitis (VO) may lead to disabling neurologic complications. Little evidence exists on optimal antibiotic management.

Methods

All patients with primary, non-implant VO, admitted from 2000–2010 were retrospectively analyzed. Patients with endocarditis, immunodeficiency, vertebral implants and surgical site infection following spine surgery were excluded. Persistence of clinical or laboratory signs of inflammation at 1 year were defined as treatment failure. Logistic regression was used to estimate the odds ratios (OR) of switch to an oral regimen after 2 weeks.

Results

Median antibiotic treatment was 8.1 weeks in 61 identified patients. Switch to oral antibiotics was performed in 72% of patients after a median intravenous therapy of 2.7 weeks. Switch to oral therapy was already performed after two weeks in 34% of the patients. A lower CRP at 2 weeks was the only independent predictor for switch to oral therapy (OR 0.7, 95% confidence interval 0.5-0.9, p = 0.041, per 10 mg/l increase). Staphylococcus aureus was the most frequently isolated microorganism (21%). Indications for surgery, other than biopsy, included debridement with drainage of epidural or paravertebral abscess (26 patients; 42%), and CT - guided drainage (3 patients).

During the follow-up, no recurrences were observed but 2 patients died of other reasons than VO, i.e. the 1 year intention to treat success rate was 97%.

Conclusions

Cure rates for non-implant VO were very high with partly short intravenous and overall antibiotic therapy. Switching to an oral antibiotic regimen after two weeks intravenous treatment may be safe, provided that CRP has decreased and epidural or paravertebral abscesses of significant size have been drained.

【 授权许可】

   
2014 Babouee Flury et al.; licensee BioMed Central Ltd.

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