Soluble toll like receptor 2 (TLR-2) is increased in saliva of children with dental caries

BMC Oral Health

Mythily Srinivasan²  Judith Chin¹  Corinne Blackburn²  Alyssa Zhao² 

[1] Department of Pediatric Dentistry, Indiana University School of Dentistry, Indianapolis, IN 46202, USA;Department of Oral Pathology, Medicine and Radiology, Indianapolis, IN 46202, USA

关键词: Biomarker;    Dental caries;    Soluble toll like receptor 2;    Saliva;   

Others  :  1092011
DOI  :  10.1186/1472-6831-14-108

 received in 2014-01-28, accepted in 2014-08-18,  发布年份 2014

【 摘 要 】

Background

Dental caries is the most common microbial disease affecting mankind. Caries risk assessment methods, identification of biomarkers and vaccine development strategies are being emphasized to control the incidence of the largely preventable disease. Pattern recognition receptors such as the toll like receptors (TLR) have been implicated as modulators of host-microbial interactions. Soluble TLR-2 and its co-receptor, CD14 identified in saliva can bind the cell wall components of cariogenic bacteria and modulate the disease process. The objective of this study is to determine the potential of salivary sTLR-2 and sCD14 as biomarkers of caries activity and indirect measures of the cariogenic bacterial burden.

Methods

Unstimulated whole saliva was collected from twenty caries free and twenty caries active children between the ages of 5 and 13 years. The concentration of sCD14 and sTLR-2 together with that of the cytokine IL-8 reported to be increased in dental caries was assessed by the enzyme linked immunosorbent assay.

Results

While the level of sCD14 and that of IL-8 was equivocal between the two groups, the sTLR-2 concentration in caries active saliva was significantly higher than that in caries free saliva.

Conclusions

The sTLR-2 in saliva could serve as a potential biomarker for caries activity.

【 授权许可】

   
2014 Zhao et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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