Association between occupational exposure and the clinical characteristics of COPD

BMC Public Health

Nicolas Roche⁷  Jean-Louis Paillasseur⁹  Graziella Brinchault^1,13  Thierry Perez¹  Christophe Pinet^1,10  Gilles Jebrak^1,11  Isabelle Court-Fortune⁵  Pierre-Régis Burgel²  Pascal Chanez⁴  Roger Escamilla⁸  Philippe Carré^1,12  Franck Lemoigne⁶  Denis Caillaud³ 

[1]Service de Pneumologie, Hôpital Calmette, J Leclerq bd, Lille 59037, France

[2]Service de Pneumologie, Hôpital Cochin, AP-HP and Paris-Descartes University, 27, Faubourg St-Jacques Str, Paris 75014, France

[3]Service de Pneumologie, Hôpital Gabriel Montpied, Montalembert Str, Clermont-Ferrand 63003, France

[4]Département des Maladies Respiratoires, AP-HM, Université de la Méditerranée, Bourelly Str, Marseille 13915, France

[5]Service de Pneumologie, CHU Saint Etienne, Albert Raimond Av, Saint Etienne 42055, France

[6]Service de Pneumologie, CHU de Nice, 30 voie romaine Av, Nice 06000, France

[7]Service de Pneumologie, Hôtel Dieu, AP-HP and Paris-Descartes University, Parvis Notre Dame Place, Paris 75004, France

[8]Clinique des voies respiratoires, Hopital Larrey, 24, Pouvourville Str, Toulouse 31059, France

[9]Clindatafirst, 12, Prés Av, St Quentin en Yvelines 78059, France

[10]Service de Pneumologie, CHG, 1208, colonel Picot Av, Toulon 83056, France

[11]Service de Pneumologie, Hôpital Bichat, 46, Henri Huchard Str, Paris 75018, France

[12]Service de Pneumologie, Hôpital Antoine Gayraud, BP 1014, Carcassonne 11890, France

[13]Service de Pneumologie, Hôpital Pontchaillou, 2, Henri Le Guillou Str, Rennes 35000, France

关键词: Exposure assessment;    COPD;    Occupational;   

Others  :  1163673
DOI  :  10.1186/1471-2458-12-302

 received in 2011-07-13, accepted in 2012-03-28,  发布年份 2012

【 摘 要 】

Background

The contribution of occupational exposures to COPD and their interaction with cigarette smoking on clinical pattern of COPD remain underappreciated. The aim of this study was to explore the contribution of occupational exposures on clinical pattern of COPD.

Methods

Cross-sectional data from a multicenter tertiary care cohort of 591 smokers or ex-smokers with COPD (median FEV1 49%) were analyzed. Self-reported exposure to vapor, dust, gas or fumes (VDGF) at any time during the entire career was recorded.

Results

VDGF exposure was reported in 209 (35%) subjects aged 31 to 88 years. Several features were significantly associated with VDGF exposure: age (median 68 versus 64 years, p < 0.001), male gender (90% vs 76%; p < 0.0001), reported work-related respiratory disability (86% vs 7%, p < 0.001), current wheezing (71% vs 61%, p = 0.03) and hay fever (15.5% vs 8.5%, p < 0.01). In contrast, current and cumulative smoking was less (p = 0.01) despite similar severity of airflow obstruction.

Conclusion

In this patient series of COPD patients, subjects exposed to VDGF were older male patients who reported more work-related respiratory disability, more asthma-like symptoms and atopy, suggesting that, even in smokers or ex-smokers with COPD, occupational exposures are associated with distinct patients characteristics.

【 授权许可】

   
2012 Caillaud et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

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