Change in paternal grandmothers´ early food supply influenced cardiovascular mortality of the female grandchildren

BMC Genetics

Michael Sjöström³  Marcus E Pembrey²  Gunnar Kaati³  Sören Edvinsson⁶  John Carstensen⁴  Petter Tinghög⁵  Lars Olov Bygren¹ 

[1] Department of Community Medicine and Rehabilitation, University of Umeå, Umeå, Sweden;Institute of Child Health, University College London, London, UK;Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden;Department of Medical and Health Sciences, University of Linköping, Linköping, Sweden;Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden;The Demographic Database, University of Umeå, Umeå, Sweden

关键词: Överkalix;    Cardiovascular mortality;    Human transgenerational response;    Environmental shock;    Food change;    Epidemiology;   

Others  :  866645
DOI  :  10.1186/1471-2156-15-12

 received in 2013-05-07, accepted in 2014-01-28,  发布年份 2014

【 摘 要 】

Background

This study investigated whether large fluctuations in food availability during grandparents' early development influenced grandchildren's cardiovascular mortality. We reported earlier that changes in availability of food - from good to poor or from poor to good - during intrauterine development was followed by a double risk of sudden death as an adult, and that mortality rate can be associated with ancestors´ childhood availability of food. We have now studied transgenerational responses (TGR) to sharp differences of harvest between two consecutive years´ for ancestors of 317 people in Överkalix, Sweden.

Results

The confidence intervals were very wide but we found a striking TGR. There was no response in cardiovascular mortality in the grandchild from sharp changes of early exposure, experienced by three of the four grandparents (maternal grandparents and paternal grandfathers). If, however, the paternal grandmother up to puberty lived through a sharp change in food supply from one year to next, her sons´ daughters had an excess risk for cardiovascular mortality (HR 2.69, 95% confidence interval 1.05-6.92). Selection or learning and imitation are unlikely explanations. X-linked epigenetic inheritance via spermatozoa seemed to be plausible, with the transmission, limited to being through the father, possibly explained by the sex differences in meiosis.

Conclusion

The shock of change in food availability seems to give specific transgenerational responses.

【 授权许可】

   
2014 Bygren et al.; licensee BioMed Central Ltd.

【 图 表 】

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