BMC Complementary and Alternative Medicine | |
Identifying Chinese herbal medicine for premenstrual syndrome: implications from a nationwide database | |
Yu-Chun Chen5  Jen-Wu Huang1  Jiun-Liang Chen4  Sien-Hung Yang4  Irene H Su3  Yi-Hsuan Lin4  Ben-Shian Huang2  Hsing-Yu Chen4  | |
[1] Department of Surgery, National Yang-Ming University Hospital, I-Lan, Taiwan;School of Medicine, National Yang-Ming University, Taipei, Taiwan;Department of Reproductive Medicine, University of California, La Jolla, San Diego, CA, USA;School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan;Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan | |
关键词: Traditional Chinese medicine; Social network analysis; National health insurance research database; Association rule mining; Premenstrual syndrome; Chinese herbal medicine; | |
Others : 1220086 DOI : 10.1186/1472-6882-14-206 |
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received in 2014-03-27, accepted in 2014-06-24, 发布年份 2014 | |
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【 摘 要 】
Background
Premenstrual syndrome (PMS) occurs in women during their reproductive age with a quite negative impact on their daily lives. Women with PMS experience a wide range of physical or psychological symptoms and seek treatment for them. Chinese herb medicine (CHM) is commonly used for PMS and the goal of this study is to investigate the prescription patterns of CHM for PMS by using a nationwide database.
Methods
Prescriptions of CHM were obtained from two million beneficiaries randomly sampled from the National Health Insurance Research Database, a nationwide database in Taiwan. The ICD-9 code 625.4 was used to identify patients with PMS. Association rule mining and social network analysis were used to explore both the combinations and the core treatments for PMS.
Results
During 1998-2011, a total of 14,312 CHM prescriptions for PMS were provided. Jia-Wei-Xiao-Yao-San (JWXYS) was the CHM which had the highest prevalence (37.5% of all prescriptions) and also the core of prescription network for PMS. For combination of two CHM, JWXYS with Cyperus rotundus L. was prescribed most frequently, 7.7% of all prescriptions, followed by JWXYS with Leonurus heterophyllus Sweet, 5.9%, and Cyperus rotundus L. with Leonurus heterophyllus Sweet, 5.6%.
Conclusions
JWXYS-centered CHM combinations were most commonly prescribed for PMS. To the best of our knowledge, this is the first pharmaco-epidemiological study to review CHM treatments for PMS. However, the efficacy and safety of these commonly used CHM were still lacking. The results of this study provide valuable references for further clinical trials and bench studies.
【 授权许可】
2014 Chen et al.; licensee BioMed Central Ltd.
【 预 览 】
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【 图 表 】
Figure 1.
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