Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease

BMC Public Health

Charumathi Sabanayagam³  Tien Y Wong⁴  E Shyong Tai⁵  Anoop Shankar¹  Ecosse L Lamoureux²  Peggy PC Chiang³ 

[1] Department of Epidemiology, West Virginia School of Public Health, Morgantown, USA;Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia;Duke-NUS Graduate Medical School, Singapore, Singapore;Department of Ophthalmology, National University of Singapore, Singapore, Singapore;University Medicine Cluster, National University Health System, Singapore, Singapore

关键词: Cardiometabolic;    Indian;    Metabolic syndrome;    Prehypertension;   

Others  :  1161952
DOI  :  10.1186/1471-2458-13-730

 received in 2013-03-01, accepted in 2013-07-26,  发布年份 2013

【 摘 要 】

Background

Prehypertension has been shown to be an early risk factor of cardiovascular disease (CVD). We investigated the prevalence and pattern of cardiometabolic risk factors in prehypertension in three ethnic Asian populations in Singapore.

Methods

We examined data from Chinese (n = 1177), Malay (n = 774), and Indian (n = 985) adults aged 40–80 years who participated in three independent population based studies conducted from 2004–2011 in Singapore who were free of diabetes, hypertension and previous CVD. Prehypertension was defined as systolic blood pressure (BP) 120–139 mm Hg or diastolic BP 80–89 mm Hg. Random blood glucose, glycated haemoglobin (HbA_1c), body mass index (BMI), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol were examined as indicators of adverse cardiometabolic profile. The association between metabolic variables and prehypertension was examined using logistic regression models adjusting for potential confounders.

Results

The prevalence of prehypertension was 59.8% (Chinese), 68.9% (Malays) and 57.7% Indians. Higher levels of blood glucose, HbA_1c and BMI were significantly associated with prehypertension in all three ethnic groups, odds ratio (95% confidence interval) of prehypertension in Chinese, Malays and Indians were: 1.42 (1.10, 1.83), 1.53 (1.05, 2.24), 1.49 (1.13, 1.98) for high-glucose; 3.50 (1.01, 12.18), 3.72 (1.29, 10.75), 2.79 (1.31, 5.94) for high-HbA_1c; 1.86 (1.34, 2.56), 2.96 (2.10, 4.18), 1.68 (1.28, 2.20) for high-BMI. In addition, higher levels of LDL cholesterol in Chinese and higher levels of triglycerides were significantly associated with prehypertension. These associations persisted when metabolic variables were analysed as continuous variables.

Conclusions

Higher levels of blood glucose, HbA_1c and BMI were associated with prehypertension in all three ethnic groups in Singapore. Screening for prehypertension and lifestyle modifications could potentially reduce the burden of CVD in otherwise healthy Asian adults living in Singapore.

【 授权许可】

   
2013 Chiang et al.; licensee BioMed Central Ltd.

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