Muscle: a source of progenitor cells for bone fracture healing

BMC Medicine

Yves Henrotin¹ 

[1] Bone and Cartilage Research Unit, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium

关键词: muscle;    progenitors;    pseudarthrosis;    fracture;    bone repair;   

Others  :  1126506
DOI  :  10.1186/1741-7015-9-136

 received in 2011-11-29, accepted in 2011-12-22,  发布年份 2011

【 摘 要 】

Bone repair failure is a major complication of open fracture, leading to non-union of broken bone extremities and movement at the fracture site. This results in a serious disability for patients. The role played by the periosteum and bone marrow progenitors in bone repair is now well documented. In contrast, limited information is available on the role played by myogenic progenitor cells in bone repair. In a recent article published in BMC Musculoskeletal Disorders, Liu et al. compared the presence of myogenic progenitor (MyoD lineage cells) in closed and open fractures. They showed that myogenic progenitors are present in open, but not closed fractures, suggesting that muscle satellite cells may colonize the fracture site in the absence of intact periosteum. Interestingly, these progenitors sequentially expressed a chondrogenic and, thereafter, an osteoblastic phenotype, suggestive of a functional role in the repair process. This finding opens up new perspectives for the research of orthopedic surgical methods, which could maximize myogenic progenitor access and mobilization to augment bone repair.

Please see related article: http://www.biomedcentral.com/1471-2474/12/288 webcite

【 授权许可】

   
2011 Henrotin; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Phieffer LS, Goulet JA: Delayed union of the tibia (Instructional Course Lecture). J Bone Joint Surg 2006, 88-A:205-216.
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• [3]Liu R, Birke O, Morse A, Peacock L, Mikulec K, Littele DG, Schindeler A: Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disord 2011, 12:288. BioMed Central Full Text