Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds

BMC Complementary and Alternative Medicine

Mirandeli Bautista-Ávila¹  Luis Jiménez- Ángeles²  Diana A Altamirano-Báez¹  Minarda De la O Arciniega¹  Mario I Ortiz³  Juan A Gayosso de Lucio¹  Raquel Cariño-Cortés³  Claudia Velázquez-González¹ 

[1]Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda la Concepción, Tilcuautla, Hidalgo, México

[2]Centro Nacional de Investigación en Imagenología e Instrumentación Médica Departamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana Unidad, Iztapalapa, Ciudad de México, México

[3]Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda la Concepción, Tilcuautla, Hidalgo, México

关键词: Ellagic acid;    Quercetin;    Geraniin;    Anti-inflammatory activity;    Antinociceptive activity;    Geranium bellum;   

Others  :  1084590
DOI  :  10.1186/1472-6882-14-506

 received in 2013-07-15, accepted in 2014-12-09,  发布年份 2014

【 摘 要 】

Background

Geranium bellum Rose, locally known as “Pata de león”, is a perennial plant distributed in the mountains of Hidalgo, Mexico. It is widely used in Mexican traditional medicine to treat fever, pain, and gastrointestinal disorders. To date, there are not published studies regarding the in vivo antinociceptive and anti-inflammatory potential of the acetone-aqueous extract from the aerial parts of G. bellum.

Methods

Antinociceptive effects of the acetone-aqueous G. bellum (AGB) extract and the isolated compounds were assessed using experimental pain models, including thermal nociception like hot plate test, and chemical nociception induced by intraperitoneal acetic acid or subplantar formalin injection in vivo. The anti-inflammatory properties of the extract were studied using systemic administration in carrageenan-induced paw edema.

Results

Intra-gastric administration of AGB (75, 150, and 300 mg/kg) showed a dose-dependent antinociceptive effect in intraperitoneal acetic acid (writhing), thermal nociception in CD1 mice, and subplantar formalin models, as well as anti-inflammatory effect in carrageenan- induced paw edema in Wistar rats. Geraniin and quercetin showed the highest antinociceptive activity in writhing test, whereas ellagic acid was the most active compound in the hot plate model.

Conclusion

These studies provide evidences that G. bellum shows antinociceptive and anti- inflammatory effects, and gives support to its use in treating pain in Mexican traditional medicine.

【 授权许可】

   
2014 Velázquez-González et al.; licensee BioMed Central.

【 图 表 】

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