Increased risk of major depression subsequent to a first-attack and non-infection caused urticaria in adolescence: a nationwide population-based study

BMC Pediatrics

Yan-Ren Lin⁴  Han-Ping Wu¹  Shinn-Ying Ho⁵  Chu-Chung Chou⁴  Chih-Yu Chang⁶  Hua-Chin Lee⁵  Wen-Liang Chen²  Hui-Ling Huang⁵  Chi-Yen Chen³  Chia-Lun Kuo³ 

[1] Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taichung Branch, 66 Section 1, Fongsing Road, Taichung 42743, Taiwan;Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan;Tsao-Tun Psychiatric Center, Nan-Tou, Taiwan;School of Medicine, Chung Shan Medical University, Taichung, Taiwan;Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan;Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan

关键词: Hazard ratio;    Pediatric;    Adolescent;    Major depression;    Non-infection caused urticaria;   

Others  :  1138599
DOI  :  10.1186/1471-2431-14-181

 received in 2014-01-27, accepted in 2014-07-09,  发布年份 2014

【 摘 要 】

Background

Non-infection caused urticaria is a common ailment in adolescents. Its symptoms (e.g., unusual rash appearance, limitation of daily activities, and recurrent itching) may contribute to the development of depressive stress in adolescents; the potential link has not been well studied. This study aimed to investigate the risk of major depression after a first-attack and non-infection caused urticaria.

Methods

This study used the Taiwan Longitudinal Health Insurance Database. A total of 5,755 adolescents hospitalized for a first-attack and non-infection caused urticaria from 2005 to 2009 were recruited as the study group, together with 17,265 matched non-urticarial enrollees who comprised the control group. Patients who had any history of urticaria or depression prior to the evaluation period were excluded. Each patient was followed for one year to identify the occurrence of depression. Cox proportional hazards models were generated to compute the risk of major depression, adjusting for the subjects’ sociodemographic characteristics. Depression-free survival curves were also analyzed.

Results

Thirty-four (0.6%) adolescents with non-infection caused urticaria and 59 (0.3%) non-urticarial control subjects suffered a new-onset episode of major depression during the study period. The stratified Cox proportional analysis showed that the crude hazard ratio (HR) of depression among adolescents with urticaria was 1.73 times (95% CI, 1.13-2.64) than that of the control subjects without urticaria. Moreover, the HR were higher in physical (HR: 3.39, 95% CI 2.77-11.52) and allergy chronic urticaria (HR: 2.43, 95% CI 3.18-9.78).

Conclusion

Individuals who have a non-infection caused urticaria during adolescence are at a higher risk of developing major depression.

【 授权许可】

   
2014 Kuo et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 3.

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