Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study

BMC Psychiatry

Sheng-Fu Liang²  Yung-Ting Chen²  Wei-Hong Chen²  Ching-I Hung¹  Ching-Wen Chao³  Kuan-Yi Wu¹ 

[1] Department of Psychiatry, Chang Gung Memorial Hospital at Linkou & College of Medicine, Chang Gung University, Taoyuan, Taiwan;Department of Computer Science and Information Engineering & Institute of Medical Informatics, National Cheng Kung University, Tainan, Taiwan;Department of Music, National Taiwan Normal University, Taipei, Taiwan

关键词: Schizophrenia;    Event-related potential;    Auditory evoked potential;    Music perception;   

Others  :  1124035
DOI  :  10.1186/1471-244X-13-158

 received in 2012-07-11, accepted in 2013-05-16,  发布年份 2013

【 摘 要 】

Background

Previous studies have demonstrated functional and structural temporal lobe abnormalities located close to the auditory cortical regions in schizophrenia. The goal of this study was to determine whether functional abnormalities exist in the cortical processing of musical sound in schizophrenia.

Methods

Twelve schizophrenic patients and twelve age- and sex-matched healthy controls were recruited, and participants listened to a random sequence of two kinds of sonic entities, intervals (tritones and perfect fifths) and chords (atonal chords, diminished chords, and major triads), of varying degrees of complexity and consonance. The perception of musical sound was investigated by the auditory evoked potentials technique.

Results

Our results showed that schizophrenic patients exhibited significant reductions in the amplitudes of the N1 and P2 components elicited by musical stimuli, to which consonant sounds contributed more significantly than dissonant sounds. Schizophrenic patients could not perceive the dissimilarity between interval and chord stimuli based on the evoked potentials responses as compared with the healthy controls.

Conclusion

This study provided electrophysiological evidence of functional abnormalities in the cortical processing of sound complexity and music consonance in schizophrenia. The preliminary findings warrant further investigations for the underlying mechanisms.

【 授权许可】

   
2013 Wu et al.; licensee BioMed Central Ltd.

【 图 表 】

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