Clinical factors affecting pathological fracture and healing of unicameral bone cysts

BMC Musculoskeletal Disorders

Yoshihiro Nishida³  Naoki Ishiguro³  Naohisa Futamura³  Eisuke Arai³  Eiji Kozawa³  Yoshihisa Yamada¹  Kenji Yamada²  Hideshi Sugiura⁴  Kozo Hosono²  Satoshi Tsukushi³  Hiroshi Urakawa³ 

[1] Department of Orthopedic Surgery, Nagoya Memorial Hospital, 4-305 Hirabari, Tenpaku-ku, Nagoya, Aichi 468-8520, Japan;Department of Orthopedic Surgery, Aichi Cancer Center Aichi Hospital, 18 Kuriyado, Kake-machi, Okazaki, Aichi 444-0011, Japan;Department of Orthopedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan;Department of Orthopedic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan

关键词: Clinical factors;    Prognosis;    Healing;    Pathological fracture;    Unicameral bone cyst;   

Others  :  1125747
DOI  :  10.1186/1471-2474-15-159

 received in 2014-01-16, accepted in 2014-05-09,  发布年份 2014

【 摘 要 】

Background

Unicameral bone cyst (UBC) is the most common benign lytic bone lesion seen in children. The aim of this study is to investigate clinical factors affecting pathological fracture and healing of UBC.

Methods

We retrospectively reviewed 155 UBC patients who consulted Nagoya musculoskeletal oncology group hospitals in Japan. Sixty of the 155 patients had pathological fracture at presentation. Of 141 patients with follow-up periods exceeding 6 months, 77 were followed conservatively and 64 treated by surgery.

Results

The fracture risk was significantly higher in the humerus than other bones. In multivariate analysis, ballooning of bone, cyst in long bone, male sex, thin cortical thickness and multilocular cyst were significant adverse prognostic factors for pathological fractures at presentation. The healing rates were 30% and 83% with observation and surgery, respectively. Multivariate analysis revealed that fracture at presentation and history of biopsy were good prognostic factors for healing of UBC in patients under observation.

Conclusion

The present results suggest that mechanical disruption of UBC such as fracture and biopsy promotes healing, and thus watchful waiting is indicated in these patients, whereas patients with poor prognostic factors for fractures should be considered for surgery.

【 授权许可】

   
2014 Urakawa et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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