Implications of screening and childcare exclusion policies for children with Shiga-toxin producing Escherichia coli infections: lessons learned from an outbreak in a daycare centre, Norway, 2012

BMC Infectious Diseases

Line Vold³  Astrid Louise Wester²  Lin Thorstensen Brandal²  Preben Aavitsland¹  Per Kjetil Dalane⁵  Emily MacDonald⁴ 

[1] Epidemi, Lasarettet, Odderøya, Kristiansand, 4610, Norway;Department of Foodborne Infections, Norwegian Institute of Public Health, Nydalen NO-0403, Oslo, Norway;Department of Infectious Disease Epidemiology, Norwegian Institute of Public Health, Nydalen NO-0403, Oslo, Norway;European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden;Municipality of Vennesla, Vennesla, 4701, Norway

关键词: Nurseries;    Child day care centers;    Child;    Disease outbreaks;    Enteropathogenic Escherichia coli;    Shiga-toxin producing Escherichia coli;    Escherichia coli;   

Others  :  1090595
DOI  :  10.1186/s12879-014-0673-2

 received in 2014-01-10, accepted in 2014-12-01,  发布年份 2014

【 摘 要 】

Background

In Norway, it is recommended that children with Shiga-Toxin producing Escherichia coli (STEC) infections are excluded from daycare centers until up to five consecutive negative stool cultures are obtained. Children with gastrointestinal illness of unknown etiology are asked to remain home for 48 hours after symptoms subside. On 16 October 2012, two cases of STEC infection were reported from a daycare center, where other children were also symptomatic. Local health authorities temporarily closed the daycare center and all children and staff were screened for pathogenic E. coli. We present the results of the outbreak investigation in order to discuss the implications of screening and the exclusion policies for children attending daycare in Norway.

Methods

Stool specimens for all children (n = 91) and employees at the daycare center (n = 40) were tested for pathogenic E. coli. Information on demographics, symptoms and potential exposures was collected from parents through trawling interviews and a web-based questionnaire. Cases were monitored to determine the duration of shedding and the resulting exclusion period from daycare.

Results

We identified five children with stx1- and eae-positive STEC O103:H2 infections, and one staff member and one child with STEC O91:H- infections. Three additional children who tested positive for stx1 and eae genes were considered probable STEC cases. Three cases were asymptomatic. Median length of time of exclusion from daycare for STEC cases was 53 days (range 9 days – 108 days). Survey responses for 75 children revealed mild gastrointestinal symptoms among both children with STEC infections and children with negative microbiological results. There was no evidence of common exposures; person-to-person transmission was likely.

Conclusions

The results of screening indicate that E. coli infections can spread in daycare centres, reflected in the proportion of children with STEC and EPEC infections. While screening can identify asymptomatic cases, the implications should be carefully considered as it can produce unanticipated results and have significant socioeconomic consequences. Daycare exclusion policies should be reviewed to address the management of prolonged asymptomatic shedders.

【 授权许可】

   
2014 MacDonald et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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