suPAR as a prognostic biomarker in sepsis

BMC Medicine

Jean-Louis Vincent¹  Cecilia Covajes¹  Sabino Scolletta¹  Katia Donadello¹ 

[1] Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, 808, route de Lennik 1070, Brussels, Belgium

关键词: suPAR;    soluble urokinase-type plasminogen activator receptor;    outcome;    case fatality;    disease severity;    biomarker;    sepsis;    infection;   

Others  :  1126453
DOI  :  10.1186/1741-7015-10-2

 received in 2011-07-29, accepted in 2012-01-05,  发布年份 2012

【 摘 要 】

Sepsis is the clinical syndrome derived from the host response to an infection and severe sepsis is the leading cause of death in critically ill patients. Several biomarkers have been tested for use in diagnosis and prognostication in patients with sepsis. Soluble urokinase-type plasminogen activator receptor (suPAR) levels are increased in various infectious diseases, in the blood and also in other tissues. However, the diagnostic value of suPAR in sepsis has not been well defined, especially compared to other more established biomarkers, such as C-reactive protein (CRP) and procalcitonin (PCT). On the other hand, suPAR levels have been shown to predict outcome in various kinds of bacteremia and recent data suggest they may have predictive value, similar to that of severity scores, in critically ill patients. This narrative review provides a descriptive overview of the clinical value of this biomarker in the diagnosis, prognosis and therapeutic guidance of sepsis.

【 授权许可】

   
2012 Donadello et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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