Association study of 15q14 and 15q25 with high myopia in the Han Chinese population

BMC Genetics

Yongyong Shi⁴  Jue Ji³  Zujia Wen³  Jiawei Shen³  Shengying Qin³  Xiangtian Zhou¹  Jia Qu¹  Zhijian Song³  Jianhua Chen²  Zhiqiang Li³  Kuanjun He³  Qingzhong Wang³  Wenjin Li³  Yu Qiang³ 

[1] Wenzhou Medical College, Wenzhou 325003, P.R China;Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P.R China;Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R China;Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai 200042, P.R China

关键词: Correlation Analysis;    Single nucleotide polymorphism;    Refractive errors;    High myopia;    RASGRF1 gene;   

Others  :  866526
DOI  :  10.1186/1471-2156-15-51

 received in 2013-10-23, accepted in 2014-04-01,  发布年份 2014

【 摘 要 】

Background

Refractive errors and high myopia are the most common ocular disorders, and both of them are leading causes of blindness in the world. Recently, genetic association studies in European and Japanese population identified that common genetic variations located in 15q14 and 15q25 were associated with high myopia. To validate whether the same variations conferred risk to high myopia in the Han Chinese population, we genotyped 1,461 individuals (940 controls and 521 cases samples) recruited of Han Chinese origin.

Result

We found rs8027411 in 15q25 (P = 0.012 after correction, OR = 0.78) was significantly associated with high myopia but rs634990 in 15q14 (P = 0.54 after correction), OR = 0.88) was not.

Conclusions

Our findings supported that 15q25 is a susceptibility locus for high myopia, and gene RASGRF1 was possible to play a role in the pathology of high myopia.

【 授权许可】

   
2014 Qiang et al.; licensee BioMed Central Ltd.

【 图 表 】

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