Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial

BMC Psychiatry

Steffen Moritz⁴  Ulrich Voderholzer³  Elisabeth Hertenstein²  Thomas Heidenreich¹  Nina Rose²  Birgit Hottenrott⁴  Barbara Cludius⁴  Sarah Landmann²  Anne Katrin Külz² 

[1] Esslingen University of Applied Sciences, Esslingen, Germany;Clinic of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany;Schoen Clinic Roseneck, Prien, Germany;Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

关键词: Randomized controlled trial;    Obsessive-compulsive disorder;    Mindfulness-based cognitive therapy;   

Others  :  1092338
DOI  :  10.1186/s12888-014-0314-8

 received in 2014-10-17, accepted in 2014-10-24,  发布年份 2014

【 摘 要 】

Background

Obsessive-compulsive disorder (OCD) is a very disabling condition with a chronic course, if left untreated. Though cognitive behavioral treatment (CBT) with or without selective serotonin reuptake inhibitors (SSRI) is the method of choice, up to one third of individuals with obsessive-compulsive disorder (OCD) do not respond to treatment in terms of at least 35% improvement of symptoms. Mindfulness based cognitive therapy (MBCT) is an 8-week group program that could help OCD patients with no or only partial response to CBT to reduce OC symptoms and develop a helpful attitude towards obsessions and compulsive urges.

Methods/design

This study is a prospective, bicentric, assessor-blinded, randomized, actively-controlled clinical trial. 128 patients with primary diagnosis of OCD according to DSM-IV and no or only partial response to CBT will be recruited from in- and outpatient services as well as online forums and the media. Patients will be randomized to either an MBCT intervention group or to a psycho-educative coaching group (OCD-EP) as an active control condition. All participants will undergo eight weekly sessions with a length of 120 minutes each of a structured group program. We hypothesize that MBCT will be superior to OCD-EP in reducing obsessive-compulsive symptoms as measured by the Yale-Brown-Obsessive-Compulsive Scale (Y-BOCS) following the intervention and at 6- and 12-months-follow-up. Secondary outcome measures include depressive symptoms, quality of life, metacognitive beliefs, self-compassion, mindful awareness and approach-avoidance tendencies as measured by an approach avoidance task.

Discussion

The results of this study will elucidate the benefits of MBCT for OCD patients who did not sufficiently benefit from CBT. To our knowledge, this is the first randomized controlled study assessing the effects of MBCT on symptom severity and associated parameters in OCD.

Trial registration

German Clinical Trials Register DRKS00004525 webcite. Registered 19 March 2013.

【 授权许可】

   
2014 Külz et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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