Preventing pre-eclampsia – are dietary factors the key?

BMC Medicine

Rosalie M Grivell¹  Cecelia O’Brien¹  Jodie M Dodd¹ 

[1] Department of Perinatal Medicine, Women’s and Babies Division, The Women’s and Children’s Hospital, North Adelaide, Australia

关键词: Dietary factors;    Randomised trials;    Systematic review;    Hypertension;    Pre-eclampsia;   

Others  :  1121434
DOI  :  10.1186/s12916-014-0176-4

 received in 2014-09-09, accepted in 2014-09-09,  发布年份 2014

【 摘 要 】

Pre-eclampsia is a common pregnancy related condition, which contributes significantly both to maternal and perinatal morbidity and mortality. The precise pathophysiology of pre-eclampsia is uncertain, and the development of effective preventive strategies remains elusive.

Schoenaker and colleagues conducted a systematic review and meta-analysis of observational studies reporting dietary intake and dietary patterns. The findings indicated that women with a low dietary calcium intake were more likely to be diagnosed with gestational hypertension, while there was a suggestion (although not statistically significant) of a beneficial effect of a diet rich in fruits and vegetables on risk of pre-eclampsia.

This is in contrast to the findings of systematic reviews and meta-analyses of randomised trials in pregnancy evaluating calcium supplementation and anti-oxidant vitamin C and E supplementation.

The validity of any systematic review is reliant on both the underlying methodology and the quality of each of the included studies; the review by Schoenaker and colleagues is limited by the observational nature of the included studies.

Please see related article: http://www.biomedcentral.com/1741-7015/12/157/abstract webcite.

【 授权许可】

   
2014 Dodd et al.; licensee BioMed Central Ltd.

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