Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies

BMC Psychiatry

Elvira Bramon¹  Shenxun Shi²  Anirban Dutt³  Yifeng Xu²  Yiyun Cai²  Liang Su³ 

[1] Mental Health Sciences Unit & Institute of Cognitive Neuroscience, University College London, London, UK;Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Psychosis studies, Institute of Psychiatry, King’s College London, De Crespigny Park, London SE5 8AF, UK

关键词: Activation likelihood estimation;    Meta-analysis;    Positron emission tomography;    Major depressive disorder;   

Others  :  1092278
DOI  :  10.1186/s12888-014-0321-9

 received in 2014-07-22, accepted in 2014-11-03,  发布年份 2014

【 摘 要 】

Background

Major depressive disorder (MDD) is a common mental illness with high lifetime prevalence close to 20%. Positron emission tomography (PET) studies have reported decreased prefrontal, insular and limbic cerebral glucose metabolism in depressed patients compared with healthy controls. However, the literature has not always been consistent. To evaluate current evidence from PET studies, we conducted a voxel-based meta-analysis of cerebral metabolism in MDD.

Method

Data were collected from databases including PubMed and Web of Science, with the last report up to April 2013. Voxel-based meta-analyses were performed using the revised activation likelihood estimation (ALE) software.

Results

Ten whole-brain-based FDG-PET studies in MDD were included in the meta-analysis, comprising 188 MDD patients and 169 healthy controls. ALE analyses showed the brain metabolism in bilateral insula, left lentiform nucleus putamen and extra-nuclear, right caudate and cingulate gyrus were significantly decreased. However, the brain activity in right thalamus pulvinar and declive of posterior lobe, left culmen of vermis in anterior lobe were significantly increased in MDD patients.

Conclusion

Our meta-analysis demonstrates the specific brain regions where possible dysfunctions are more consistently reported in MDD patients. Altered metabolism in insula, limbic system, basal ganglia, thalamus, and cerebellum and thus these regions are likely to play a key role in the pathophysiology of depression.

【 授权许可】

   
2014 Su et al.; licensee BioMed Central Ltd.

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