β cells keep bad epigenetic memories of palmitate

BMC Medicine

Pierre Bougnères²  Delphine Fradin¹ 

[1] Inserm U986, Pincus Building, Bicêtre Hospital, Paris Sud University, 94275 Le Kremlin Bicêtre, France;AP-HP, Department of Pediatric Endocrinology, Bicêtre Hospital, Pôle I3E, Paris Sud University, rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France

关键词: DNA methylation;    obesity;    islets of Langerhans;    type 2 diabetes;    gene expression;    epigenetics;    palmitate;    fatty acids;    pancreatic cells;   

Others  :  797854
DOI  :  10.1186/1741-7015-12-104

 received in 2014-06-12, accepted in 2014-06-12,  发布年份 2014

【 摘 要 】

Palmitic acid, or hexadecanoic acid, a 16-carbon saturated fatty acid (FA), accounts for approximately 38% of the total circulating FA in lean or obese humans. In an article published in BMC Medicine, Hall et al. report that cultured islets from healthy donors, when exposed to palmitate, undergo changes in CpG methylation that are associated with modifications of expression in 290 genes. Their results provide a first look at the mechanisms used by the endocrine pancreas of humans to keep a durable genomic imprint from their exposure to FA that can influence gene expression and possibly cell phenotype in the long term. It is likely that such studies will help understand the epigenetic response of β cells to a disturbed metabolic environment, especially one created by obesity.

Please see related article: http://www.biomedcentral.com/1741-7015/12/103 webcite

【 授权许可】

   
2014 Fradin and Bougnères; licensee BioMed Central Ltd.

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