The impact of maternal smoking during pregnancy on depressive and anxiety behaviors in children: the Norwegian Mother and Child Cohort Study

BMC Medicine

Michael Berk²  Julie A Pasco³  Felice N Jacka¹  Evalill Bølstad Karevold⁶  Simon Øverland⁵  Kristin Gustavson⁴  Steven Moylan² 

[1] School of Medicine, Deakin University, Geelong 3220, Victoria, Australia;Barwon Health, Geelong 3220, Victoria, Australia;NorthWest Academic Centre, Department of Medicine, The University of Melbourne, St Albans 3021, Victoria, Australia;Division of Mental Health, Norwegian Institute of Public Health, Oslo NO-0403, Norway;Faculty of Psychology, University of Bergen, Bergen N-5020, Norway;Department of Psychology, University of Oslo, Oslo NO-0316, Norway

关键词: Psychiatry;    Obstetrics;    Pregnancy;    Cigarette smoking;    Depression;    Anxiety;   

Others  :  1118660
DOI  :  10.1186/s12916-014-0257-4

 received in 2014-05-09, accepted in 2014-12-12,  发布年份 2015

【 摘 要 】

Background

Maternal smoking during pregnancy (MSDP) is associated with multiple adverse childhood outcomes including externalizing behaviors. However, the association between MSDP and internalizing (anxiety and depressive) behaviors in offspring has received less investigation. We aimed to assess the association between MSDP and childhood internalizing (anxiety and depressive) behaviors in a very large, well-characterized cohort study.

Methods

We assessed the association between MSDP and internalizing behaviors in offspring utilizing information drawn from 90,040 mother-child pairs enrolled in the Norwegian Mother and Child Cohort Study. Mothers reported smoking information, including status and frequency of smoking, twice during pregnancy. Mothers also reported their child’s internalizing behaviors at 18 months, 36 months, and 5 years. Associations between MSDP and childhood internalizing behaviors, including dose-response and timing of smoking in pregnancy, were assessed at each time point.

Results

MSDP was associated with increased internalizing behaviors when offspring were aged 18 months (B = 0.11, P <0.001) and 36 months (B = 0.06, P <0.01), adjusting for numerous potential confounders. Higher rates of smoking (e.g., >20 cigarettes per day) were associated with higher levels of internalizing behaviors. Maternal smoking during early pregnancy appeared to be the critical period for exposure.

Conclusions

We found evidence supporting a potential role for MSDP in increasing internalizing (anxiety and depressive) behaviors in offspring. We also found evidence supportive of a possible causal relationship, including dose-dependency and support for a predominant role of early pregnancy exposure. Further investigation utilizing genetically informed designs are warranted to assess this association.

【 授权许可】

   
2015 Moylan et al.; licensee BioMed Central.

【 图 表 】

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