The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

BMC Psychiatry

Samantha J Brooks⁴  George Fein¹  Raj Ramesar³  Natalie L Cuzen⁴  Valerie Cardenas¹  Karestan Koenen²  Dan J Stein⁴  Shareefa Dalvie³ 

[1] Neurobehavioral Research Inc, Honolulu, HI, USA;Mailman School of Public Health, Columbia University, New York, NY, USA;MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa;Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa

关键词: Voxel-based morphometry;    Magnetic resonance imaging;    Alcohol use disorders;    Childhood trauma questionnaire;   

Others  :  1091238
DOI  :  10.1186/s12888-014-0328-2

 received in 2014-08-11, accepted in 2014-11-10,  发布年份 2014

【 摘 要 】

Background

Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life adversity, genetic factors (e.g. p.Met66 allele of BDNF), and alcohol dependence, on brain structure in adolescents is limited. We examined whether the BDNF p.Val66Met polymorphism interacts with childhood trauma to predict alterations in brain volume in adolescents with alcohol use disorders (AUDs).

Methods

We examined 160 participants (80 adolescents with DSM-IV AUD and 80 age- and gender-matched controls) who were assessed for trauma using the Childhood Trauma Questionnaire (CTQ). Magnetic resonance images were acquired for a subset of the cohort (58 AUD and 58 controls) and volumes of global and regional structures were estimated using voxel-based morphometry (VBM). Samples were genotyped for the p.Val66Met polymorphism using the TaqMan® Assay. Analysis of covariance (ANCOVA) and post-hoc t-tests were conducted using SPM8 VBM.

Results

No significant associations, corrected for multiple comparisons, were found between the BDNF p.Val66Met polymorphism, brain volumes and AUD in adolescents with childhood trauma.

Conclusions

These preliminary findings suggest that the BDNF p.Met66 allele and childhood trauma may not be associated with reduced structural volumes in AUD. Other genetic contributors should be investigated in future studies.

【 授权许可】

   
2014 Dalvie et al.; licensee BioMed Central.

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