Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus

BMC Neuroscience

Josef Halámek¹  Pavel Jurák¹  Pavel Daniel⁴  Matt M Stead⁵  Daniel J Shaw²  Robert Roman³  Jan Cimbálník⁶  Milan Brázdil⁴ 

[1] Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic;Behavioural and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic;Department of Physiology, Medical Faculty of Masaryk University, Brno, Czech Republic;Department of Neurology, Brno Epilepsy Center, St. Anne’s University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno 65691, Czech Republic;Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, MN, USA;International Clinical Research Center, St. Anne’s University Hospital, Brno, Czech Republic

关键词: Human cognition;    Epilepsy;    Hippocampal ripples;    High-frequency oscillations;   

Others  :  1228618
DOI  :  10.1186/s12868-015-0184-0

 received in 2015-01-19, accepted in 2015-07-13,  发布年份 2015

【 摘 要 】

Background

Until now there has been no way of distinguishing between physiological and epileptic hippocampal ripples in intracranial recordings. In the present study we addressed this by investigating the effect of cognitive stimulation on interictal high frequency oscillations in the ripple range (80–250 Hz) within epileptic (EH) and non-epileptic hippocampus (NH).

Methods

We analyzed depth EEG recordings in 10 patients with intractable epilepsy, in whom hippocampal activity was recorded initially during quiet wakefulness and subsequently during a simple cognitive task. Using automated detection of ripples based on amplitude of the power envelope, we analyzed ripple rate (RR) in the cognitive and resting period, within EH and NH.

Results

Compared to quiet wakefulness we observed a significant reduction of RR during cognitive stimulation in EH, while it remained statistically marginal in NH. Further, we investigated the direct impact of cognitive stimuli on ripples (i.e. immediately post-stimulus), which showed a transient statistically significant suppression of ripples in the first second after stimuli onset in NH only.

Conclusion

Our results point to a differential reactivity of ripples within EH and NH to cognitive stimulation.

【 授权许可】

   
2015 Brázdil et al.

【 图 表 】

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