Retinal changes in visceral leishmaniasis by retinal photography

BMC Infectious Diseases

Mohammad Abul Faiz²  Arjen M Dondorp¹  Baljean Dhillon⁶  Shyamanga Borooah⁶  Thomas J MacGillivray³  Laura Hughes⁶  Abdullah Abu Sayeed⁵  Darryl Braganza Menezes⁴  Mohammed Ishaque Majumder²  Ridwanur Rahman²  Abu Hayat Md Waliur Rahman²  BUM Wahid Ahmed²  Richard James Maude⁶ 

[1] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK;Sir Salimullah Medical College, Dhaka, Bangladesh;Clinical Research Imaging Centre. Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK;Queen Elizabeth Hospital, Birmingham, UK;Chittagong Medical College Hospital, Chittagong, Bangladesh;College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK

关键词: Kala-azar;    Bangladesh;    Visceral;    Retinopathy;    Retina;    Leishmaniasis;   

Others  :  1125471
DOI  :  10.1186/1471-2334-14-527

 received in 2014-05-12, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

In visceral leishmaniasis (VL), retinal changes have previously been noted but not described in detail and their clinical and pathological significance are unknown. A prospective observational study was undertaken in Mymensingh, Bangladesh aiming to describe in detail visible changes in the retina in unselected patients with VL.

Methods

Patients underwent assessment of visual function, indirect and direct ophthalmoscopy and portable retinal photography. The photographs were assessed by masked observers including assessment for vessel tortuosity using a semi-automated system.

Results

30 patients with VL were enrolled, of whom 6 (20%) had abnormalities. These included 5 with focal retinal whitening, 2 with cotton wool spots, 2 with haemorrhages, as well as increased vessel tortuosity. Visual function was preserved.

Conclusions

These changes suggest a previously unrecognized retinal vasculopathy. An inflammatory aetiology is plausible such as a subclinical retinal vasculitis, possibly with altered local microvascular autoregulation, and warrants further investigation.

【 授权许可】

   
2014 Maude et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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