Adalimumab for orbital myositis in a patient with Crohn’s disease who discontinued infliximab: a case report and review of the literature

BMC Gastroenterology

Richard N Fedorak¹  Karen I Kroeker¹  Sanam Verma¹ 

[1]Division of Gastroenterology, University of Alberta, Zeidler Ledcor Center, Edmonton, Alberta, T6G 2X8, Canada

关键词: Adalimumab;    Infliximab;    Inflammatory bowel disease;    Extraintestinal manifestations;    Orbital myositis;    Ulcerative colitis;    Crohn’s disease;   

Others  :  858100
DOI  :  10.1186/1471-230X-13-59

 received in 2012-10-09, accepted in 2013-02-25,  发布年份 2013

【 摘 要 】

Background

Orbital myositis is a rare extra-intestinal manifestation of inflammatory bowel disease. Seventeen cases of Crohn’s disease associated orbital myositis and 3 cases of ulcerative colitis associated orbital myositis have been reported in the published literature since 1970. We report the use of adalimumab (Abbott, Canada, Inc.) for orbital myositis in a patient with Crohn’s disease who discontinued infliximab (Janssen, Canada, Inc.) and review of the published literature.

Case presentation

A 35 year-old male with a 7-year history of Crohn’s disease was treated with an ileocolonic resection and re-anastomosis followed by infliximab which maintained full endoscopic and clinical remission for four years. After stopping the infliximab for infusion-related reactions he presented with 3-day history of severe right eye pain, pain with ocular movement, proptosis, and conjunctival injection. He had no intestinal symptoms and endoscopic assessment revealed no active luminal disease. CT of the orbit revealed an enlarged right medial rectus muscle with tendonous involvement and a diagnosis of orbital myositis was made. Treatment with 80 mg per day prednisone with tapering dose and adalimumab, induction and maintenance, resulted in rapid resolution of the orbital myositis and ocular symptoms with no recurrences on follow-up at 10 months.

Conclusions

The current case demonstrates a rare extraintestinal manifestation of Crohn’s disease, orbital myositis, and its temporal relationship to the discontinuance of infliximab therapy and its successful treatment, without recurrence with tapering prednisone and adalimumab.

【 授权许可】

   
2013 Verma et al.; licensee BioMed Central Ltd.

【 图 表 】

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