Differential associations of central and brachial blood pressure with carotid atherosclerosis and microvascular complications in patients with type 2 diabetes

BMC Cardiovascular Disorders

Ji-Oh Mok¹  Sung-Koo Kang¹  Chul-Hee Kim¹  Bo-Yeon Kim¹  Kyu-Jin Kim¹  Sang-Hee Jung²  Chan-Hee Jung¹ 

[1]Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, South Korea

[2]Department of Obstetrics and Gynecology, Cha University School of Medicine, Bundang, Korea

关键词: Type 2 diabetes;    Carotid atherosclerosis;    Microvascular complications;    Brachial blood pressure;    Central blood pressure;   

Others  :  855375
DOI  :  10.1186/1471-2261-14-23

 received in 2013-12-11, accepted in 2014-02-17,  发布年份 2014

【 摘 要 】

Background

We examined the relationship between central blood pressure (BP), brachial BP with carotid atherosclerosis and microvascular complications in type 2 diabetes mellitus (T2DM).

Methods

We recruited 201 patients who were evaluated for central BP, brachial BP, carotid ultrasonography, brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI) and microvascular complications. Central BP were calculated using a radial automated tonometric system.

Results

Agreement between central BP and brachial BP was very strong (concordance correlation coefficient between central and brachial SBP = 0.889, between central and brachial PP = 0.816). Central pulse pressure (PP) was correlated with mean carotid intima-media thickness (CIMT), baPWV and ABI, whereas brachial PP was borderline significantly correlated with CIMT. The prevalence of nephropathy(DN) and retinopathy(DR) according to the brachial PP tertiles increased, the prevalences of microvascular complications were not different across central PP tertiles. In multivariate analysis, the relative risks (RRs) for the presence of DR were 1.2 and 4.6 for the brachial PP tertiles 2 and 3 when compared with the first tertile. Also, the RRs for the presence of DN were 1.02 and 3 for the brachial PP tertiles 2 and 3 when compared with the first tertile.

Conclusions

Agreement of central BP and brachial BP was very strong. Nonetheless, this study showed that higher brachial PP levels are associated with increased probability for the presence of microvascular complications such as DR/DN. However, there are no associations with central SBP and central PP with microvascular complications. Central BP levels than brachial BP are correlated with surrogate marker of macrovascular complications.

【 授权许可】

   
2014 Jung et al.; licensee BioMed Central Ltd.

【 图 表 】

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