AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000–2008: hospital-based cohort studies

BMC Infectious Diseases

Geneviève Chêne⁴  Beatriz Grinsztejn²  François Dabis⁴  Valdilea Gonçalves Veloso²  Charles Cazanave¹  Carine Greib³  Dayse Perreira Campos²  Mojgan Hessamfar⁴  Ronaldo Ismério Moreira²  Fabrice Bonnet⁴  Sayonara Ribeiro²  Mathias Bruyand⁴  Paula Mendes Luz² 

[1] Centre Hospitalier Universitaire de Bordeaux, Hôpital Pellegrin, Bordeaux F-33000, France;Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040, Rio de Janeiro, Brasil;Centre Hospitalier Universitaire de Bordeaux, Hôpital Haut-Lévèque, Pessac F-33600, France;INSERM, ISPED, Centre Inserm U897- Epidemiologie-Biostatistique & CIC-EC7, Bordeaux F-33000, France

关键词: France;    Brazil;    Cohort study;    Hospitalization;    Severe morbidity;    Antiretroviral therapy;    AIDS;    HIV;   

Others  :  1127759
DOI  :  10.1186/1471-2334-14-278

 received in 2014-01-14, accepted in 2014-05-06,  发布年份 2014

【 摘 要 】

Background

In high-income settings, the spectrum of morbidity and mortality experienced by Human Immunodeficiency Virus (HIV)-infected individuals receiving combination antiretroviral therapy (cART) has switched from predominantly AIDS-related to non-AIDS-related conditions. In the context of universal access to care, we evaluated whether that shift would apply in Brazil, a middle-income country with universal access to treatment, as compared to France.

Methods

Two hospital-based cohorts of HIV-infected individuals were used for this analysis: the ANRS CO3 Aquitaine Cohort in South Western France and the Evandro Chagas Research Institute (IPEC) Cohort of the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Severe morbid events (AIDS- and non-AIDS-related) were defined as all clinical diagnoses associated with a hospitalization of ≥48 hours. Trends in the incidence rate of events and their determinants were estimated while adjusting for within-subject correlation using generalized estimating equations models with an auto-regressive correlation structure and robust standard errors.

Result

Between January 2000 and December 2008, 7812 adult patients were followed for a total of 41,668 person-years (PY) of follow-up. Throughout the study period, 90% of the patients were treated with cART. The annual incidence rate of AIDS and non-AIDS events, and of deaths significantly decreased over the years, from 6.2, 21.1, and 1.9 AIDS, non-AIDS events, and deaths per 100 PY in 2000 to 4.3, 14.9, and 1.5/100 PY in 2008. The annual incidence rates of non-AIDS events surpassed that of AIDS-events during the entire study period. High CD4 cell counts were associated with a lower incidence rate of AIDS and non-AIDS events as well as with lower rates of specific non-AIDS events, such as bacterial, hepatic, viral, neurological, and cardiovascular conditions. Adjusted analysis showed that severe morbidity was associated with lower CD4 counts and higher plasma HIV RNAs but not with setting (IPEC versus Aquitaine).

Conclusions

As information on severe morbidities for HIV-infected patients remain scarce, data on hospitalizations are valuable to identify priorities for case management and to improve the quality of life of patients with a chronic disease requiring life-long treatment. Immune restoration is highly effective in reducing AIDS and non-AIDS severe morbid events irrespective of the setting.

【 授权许可】

   
2014 Luz et al.; licensee BioMed Central Ltd.

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