期刊论文详细信息
BMC Research Notes
Gastric Leiomyosarcoma as a rare cause of gastric outlet obstruction and perforation: a case report
Marcelin Ngowe Ngowe1  George Enoworock2  Elroy P Weledji1 
[1] Department of Surgery, Faculty of Health Sciences, University of Buea, PO Box 126 Limbe, S.W. Region, Buea, Cameroon;Department of Pathology, Faculty of Health Sciences, University of Buea, Buea, Cameroon
关键词: Gastrointestinal stromal tumours;    Leiomyosarcoma;    Gastric outlet obstruction;   
Others  :  1131790
DOI  :  10.1186/1756-0500-7-479
 received in 2014-03-29, accepted in 2014-07-25,  发布年份 2014
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【 摘 要 】

Background

Gastrointestinal stromal tumours are the most common mesenchymal malignancies of the gastrointestinal (GI) tract and gastric leiomyosarcoma represent 1-3% of gastric malignancies.

Case presentation

We report a case of a 69-year- old black African man who presented with a rare cause of gastric outlet obstruction and duodenal perforation. A Billroth- II gastrectomy was performed and histology confirmed a gastric leiomyosarcoma.

Conclusions

It is important to identify the gastric leiomyosarcoma which is a variant of the more common malignant gastrointestinal stromal tumours as the pathogenesis and management are currently well established. As the facilities for differentiating these are not easily available in resource-limited areas gastrointestinal stromal tumours may remain underdiagnosed and undertreated.

【 授权许可】

   
2014 Weledji et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Appelman HD: Smooth muscle tumours of the gastrointestinal tract. What we know now that Stout didn’t know. Am J Surg Pathol 1986, 10(S1):83-99.
  • [2]Lehnert T, Sinn HP, Waldherr R: Surgical treatment of soft tissue tumours of the stomach. Eur J Surg Oncol 1990, 10:352-359.
  • [3]Graadt van Roggen JF, van Velthuysen MLF, Hogendoorn PCW: The histopathological differential diagnosis of gastrointestinal stromal tumours. J Clin Pathol 2001, 54:96-102.
  • [4]Van de Rijn M, Hendrickson MR, Rouse RV: The CD34 expression by the Gastrointestinal stromal tumours. Hum Pathol 1994, 25:661-771.
  • [5]Leeman MF, Skouras C, Paterson Brown S: The management of perforated gastric ulcers. Int J Surg 2013, 11(4):322-324.
  • [6]Shepherd JA: Perforation of leiomyosarcoma of stomach. Br J Surg 1950, 97:479-481.
  • [7]Grant CS, Kim CH, Farrugia G, Zinsmeister A, Goellner JR: Gastric Leiomyosarcoma. Prognostic factors and surgical management. Arch Surg 1991, 126:985-990.
  • [8]O’Hanlon DM, Griffin SM: Management of other oesophageal and gastric neoplasms. In Upper Gastrointestinal surgery. A companion to specialist surgical practice. Edited by Michael Griffin S, Raimes SA. London, NW1 7DX, England: WB Saunders Company Ltd; 2000.
  • [9]Connolly EM, Gaffney E, Reynolds JV: Gastrointestinal stromal tumours. Br J Surg 2003, 90:1178-1186.
  • [10]Fielding LP, Phillips RK, Fry JS, Hittinger R: Prediction of outcome after curative surgery for large bowel cancer. Lancet 1986, ii:904-906.
  • [11]Fletcher JA: The molecular pathogenesis of gastrointestinal stromal tumours. Monographs in Gastrointestinal stromal tumors 2003, 1(1&2):15-20.
  • [12]Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, Patel S, McCarter MD, Polikoff JA, Tan BR, Owzar K, American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team: Adjuvant imatinib mesylate after resection of localized, primary gastrointestinal stromal tumour: a randomized, double-blind, placebo-controlled trial. Lancet 2009, 373:1097-1104.
  • [13]Kantharia CV, Irpatigire R, Prabbhu RY, Bapat RD, Supe AN: Varied presentations of gastrointestinal stromal tumour. Indian J Surg 2008, 70:318-321.
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