Delayed diagnosis of coeliac disease increases cancer risk

BMC Gastroenterology

Massimo De Vincenzi²  Rita Di Benedetto²  Mariarita Dessì³  Anna Maria Mecchia²  Umberto Volta¹  Marco Silano² 

[1]Department of Internal Medicine, S. Orsola-Malpighi Hospital, Viale Massarenti 9, Bologna, Italy

[2]Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy

[3]Department of Laboratory Medicine, University Hospital Tor Vergata, Viale Oxford 81, Rome, Italy

Others  :  1211664
DOI  :  10.1186/1471-230X-7-8

 received in 2006-08-28, accepted in 2007-03-09,  发布年份 2007

【 摘 要 】

Background

The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease.

Methods

The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1^st January 1982 and 31^st March 2005.

Results

The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not.

Conclusion

Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in advancing age.

【 授权许可】

   
2007 Silano et al; licensee BioMed Central Ltd.

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