Comparison of lower extremity atherosclerosis in diabetic and non-diabetic patients using multidetector computed tomography

BMC Cardiovascular Disorders

Ming Gu²  Zhi-gang Yang⁴  Fei-zhou Du²  Jian Rong¹  Yun-ming Li³  Jin-gang Yang²  Ci He² 

[1] Division of Geriatric Medicine, Department of Medicine, Chengdu Military General Hospital, Chengdu, Sichuan 610083, China;Department of Radiology, Chengdu Military General Hospital, Chengdu, Sichuan 610083, China;Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, China;Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

关键词: Angiography;    Computed tomography;    Atherosclerosis;    Lower extremity;    Diabetes mellitus;   

Others  :  1088717
DOI  :  10.1186/1471-2261-14-125

 received in 2014-05-25, accepted in 2014-09-22,  发布年份 2014

【 摘 要 】

Background

Lower extremity atherosclerosis (LEA) is among the most serious diabetic complications and leads to non-traumatic amputations. The recently developed dual-source CT (DSCT) and 320- multidetector computed tomography (MDCT) may help to detect plaques more precisely. The aim of our study was to evaluate the differences in LEA between diabetic and non-diabetic patients using MDCT angiography.

Methods

DSCT and 320-MDCT angiographies of the lower extremities were performed in 161 patients (60 diabetic and 101 non-diabetic). The plaque type, distribution, shape and obstructive natures were compared.

Results

Compared with non-diabetic patients, diabetic patients had higher peripheral neuropathy, history of cerebrovasuclar infarction and hypertension rates. A total of 2898 vascular segments were included in the analysis. Plaque and stenosis were detected in 681 segments in 60 diabetic patients (63.1%) and 854 segments in 101 non-diabetic patients (46.9%; p <0.05). Regarding these plaques, diabetic patients had a higher incidence of mixed plaques (34.2% vs. 27.1% for non-diabetic patients). An increased moderate stenosis rate and decreased occlusion rate were observed in diabetic patients relative to non-diabetic patients (35.8% vs. 28.3%; and 6.6% vs. 11.4%; respectively). In diabetic patients, 362 (53.2%) plaques were detected in the distal lower leg segments, whereas in non-diabetic patients, 551 (64.5%) plaques were found in the proximal upper leg segments. The type IV plaque shape, in which the full lumen was involved, was detected more frequently in diabetic patients than in non-diabetic patients (13.1% vs. 8.2%).

Conclusion

Diabetes is associated with a higher incidence of plaque, increased incidence of mixed plaques, moderate stenosis and localisation primarily in the distal lower leg segments. The advanced and non-invasive MDCT could be used for routine preoperative evaluations of LEA.

【 授权许可】

   
2014 He et al.; licensee BioMed Central Ltd.

【 图 表 】

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