Therapeutic effects of maximal strength training on walking efficiency in patients with schizophrenia – a pilot study

BMC Research Notes

Jan Hoff¹  Geir E Nilsberg²  Jan Helgerud³  Gunnar Morken²  Jørn Heggelund² 

[1] Department of Physical Medicine and Rehabilitation, St.Olavs University Hospital, Trondheim, Norway;Division of Psychiatry, Department of Østmarka, St. Olavs University Hospital, Trondheim, Norway;Department of Sports and Outdoor Life Studies, Telemark University College, Bø, Norway

关键词: Schizophrenia;    Walking efficiency;    Gait disturbances;    Exercise;   

Others  :  1166170
DOI  :  10.1186/1756-0500-5-344

 received in 2011-12-20, accepted in 2012-04-25,  发布年份 2012

【 摘 要 】

Background

Patients with schizophrenia frequently have disabling gait deficits. The net mechanical efficiency of walking (ϵ_net) is an accurate measure often used to evaluate walking performance. Patients with gait deficits have a reduced ϵ_net with excessive energy expenditure during sub-maximal walking. Maximal strength training (MST) improves ϵ_net in healthy individuals and is associated with reduced risk of mortality. The aim of this study was to investigate whether MST improves ϵ_net in patients with schizophrenia.

Methods

Patients (ICD-10 schizophrenia, schizotypal or delusional disorders (F20-F29)) were included in a non-randomized trial. Patients were assigned to one of two groups: 1) MST consisting of 4x4 repetitions at 85-90% one repetition maximum (1RM) performed in a leg press apparatus or 2) playing computer games (CG). Both groups carried out their activity three days per week for eight weeks. 1RM, ϵ_net at 60 watt walking, peak oxygen uptake (VO_2peak), the Positive and Negative Syndrome Scale (PANSS) and the 36-items short form (SF-36) were measured pre and post intervention.

Results

The baseline ϵ_net was 17.3 ± 1.2% and 19.4 ± 3.0% in the MST (n = 6) and CG groups (n = 7), respectively, which is categorized as mechanical inefficiency. The MST group improved 1RM by 79 kg (p = 0.006) and ϵ_net by 3.4% (p = 0.046) more than the CG group. The MST group improved 1RM and ϵ_net, by a mean of 83 kg (p = 0.028) and 3.4% (p = 0.028), respectively. VO_2peak at baseline was 34.2 ± 10.2 and 38.3 ± 9.8 ml·kg^-1·min^-1 in the MST and CG groups, respectively, and did not change (p > 0.05). No change was observed in PANSS or SF-36 (p > 0.05).

Conclusions

MST improves 1RM and ϵ_net in patients with schizophrenia. MST could be used as a therapeutic intervention for patients with schizophrenia to normalize their reduced ϵ_net.

【 授权许可】

   
2012 Heggelund et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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