Factors associated with 24-hour urinary volume: the Swiss salt survey

BMC Nephrology

David Conen¹  Murielle Bochud²  Michel Burnier³  Fred Paccaud²  Jonas Blum¹  Tobias Schoen¹ 

[1] Department of Medicine, University Hospital, Basel, Switzerland;Community Prevention Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland;Service of Nephrology and Hypertension, Lausanne University Hospital, Lausanne, Switzerland

关键词: Salt excretion;    Gender;    Salt;    Population based study;    Prevention;    Kidney function;    Daily urinary volume;   

Others  :  1082793
DOI  :  10.1186/1471-2369-14-246

 received in 2013-05-21, accepted in 2013-10-29,  发布年份 2013

【 摘 要 】

Background

Low 24-hour urine volume (24UV) may be a significant risk factor for decline in kidney function. We therefore aimed to study associated markers and possible determinants of 24UV in a sample of the Swiss population.

Methods

The cross-sectional Swiss Salt Study included a population-based sample of 1535 (746 men and 789 women) individuals from three linguistic regions of Switzerland. Data from 1300 subjects were available for the present analysis. 24UV was measured using 24-hour urine collection. Determinants of 24UV were identified using multivariable linear regression models.

Results

In bivariate analysis, 24UV was higher in women compared to men (2000 ml/24 h [interquartile range (IQR): 1354, 2562] versus 1780 ml/24 h [IQR: 1244, 2360], p = 0.002). In multivariable regression analyses, independent associated markers of 24UV were female sex (β = 280, 95% confidence interval [CI]: 174, 386, p < 0.0001), fluid intake (β = 604, 95% CI: 539, 670, p < 0.0001), sodium excretion (β = 4.2, 95% CI: 3.4, 4.9, p < 0.0001) age (β = 6.6, CI: 3.4, 9.7, p < .0001), creatinine clearance (β = 2.4, CI: 0.2, 4.6, p = 0.04), living in the German-speaking part of Switzerland (β = 124, CI: 29, 219, p = 0.01), alcohol consumption (β = 41, CI: 9, 73, p = 0.01 for increasing categories of alcohol consumption), body mass index (β = −32, CI: -45, -18, p < 0.0001), current smoking (β = −146, CI: -265, -26, p = 0.02), and consumption of meat and cold cut (β = −56, CI: -108, -5, p = 0.03).

Conclusion

In this large population-based, cross-sectional study, we found several strong and independent correlates for 24UV. These findings may be important to improve our understanding in the development of chronic kidney disease.

【 授权许可】

   
2013 Schoen et al.; licensee BioMed Central Ltd.

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