Schwann cell hamartoma: case report

BMC Gastroenterology

Solange Romagnoli³  Gaetano Bulfamante³  Paola Braidotti³  Franca Di Nuovo¹  Laura Moneghini³  Monica Falleni³  Alessandra Dell'Era²  Francesca Iannuzzi²  Elena Guerini Rocco³ 

[1]Azienda Ospedaliera G.Salvini, Garbagnate Milanese, Italy

[2]Department of Clinical Sciences "Luigi Sacco", University of Milan Medical School, Milan, Italy

[3]Department of Medicine, Surgery and Dentistry, Division of Pathology, A.O. San Paolo and Fondazione IRCCS Cà-Granda Ospedale Maggiore Policlinico, University of Milan Medical School, Milan, Italy

关键词: colonic polyp;    gastrointestinal stromal tumors;    schwannoma;    hamartoma;    Schwann cell;   

Others  :  1114485
DOI  :  10.1186/1471-230X-11-68

 received in 2011-02-22, accepted in 2011-06-10,  发布年份 2011

【 摘 要 】

Background

Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.

Case presentation

We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.

Conclusion

As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

【 授权许可】

   
2011 Rocco et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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