BMC Cardiovascular Disorders | |
Left ventricular geometric patterns and adaptations to hemodynamics are similar in elderly men and women | |
Lars Lind1  Johan Sundström1  Said Masiha2  | |
[1] Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden;Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden | |
关键词: Doppler; echocardiography; left ventricular hypertrophy; Left ventricular geometry; Gender; | |
Others : 1086016 DOI : 10.1186/1471-2261-11-25 |
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received in 2010-09-17, accepted in 2011-05-27, 发布年份 2011 | |
【 摘 要 】
Background
Common conditions such as obesity and hypertension result in hemodynamic alterations that will induce remodeling of the left ventricle (LV). However, differences between the genders in the relationship of hemodynamics to LV geometry are not well known.
The present study aims to investigate differences between the genders in this respect, in a sample of elderly persons.
Methods
Echocardiography and Doppler was performed in a population-based sample aged 70 - The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 922).
Hemodynamic patterns obtained by echocardiography and Doppler were evaluated in relation to four LV geometric groups (normal, concentric remodeling, eccentric hypertrophy and concentric hypertrophy).
Results
No significant difference between the genders was observed regarding the prevalence of the LV geometric groups.
Mean values of most evaluated echocardiography and Doppler variables differed between men and women, such as LA, IVS, LVEDD and IVRT, but the relationship of hemodynamic variables to LV geometric groups did not differ between the genders.
Conclusions
Although mean values of many echocardiographic variables differed between men and women, the LV geometric adaptations to a given hemodynamic load appear similar in both genders.
【 授权许可】
2011 Masiha et al; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20150113182510155.pdf | 176KB | download | |
Figure 1. | 33KB | Image | download |
【 图 表 】
Figure 1.
【 参考文献 】
- [1]Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP: Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990, 322:1561-6.
- [2]Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP: Left ventricular mass and incidence of coronary heart disease in an elderly cohort. The Framingham Heart Study. Ann Intern Med 1989, 110:101-7.
- [3]Casale PN, Devereux RB, Milner M, Zullo G, Harshfield GA, Pickering TG, Laragh JH: Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann Intern Med 1986, 105:173-8.
- [4]Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH: Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 1991, 114:345-52.
- [5]Curb JD, Borhani NO, Entwisle G, Tung B, Kass E, Schnaper H, Williams W, Berman R: Isolated systolic hypertension in 14 communities. Am J Epidemiol 1985, 121:362-70.
- [6]Garland C, Barrett-Connor E, Suarez L, Criqui MH: Isolated systolic hypertension and mortality after age 60 years. A prospective population-based study. Am J Epidemiol 1983, 118:365-76.
- [7]Staessen J, Fagard R, Amery A: Isolated systolic hypertension in the elderly: implications of Systolic Hypertension in the Elderly Program (SHEP) for clinical practice and for the ongoing trials. J Hum Hypertens 1991, 5:469-74.
- [8]Papademetriou V, Devereux RB, Narayan P, Wachtell K, Bella JN, Gerdts E, Chrysant SG, Dahlöf B: Similar effects of isolated systolic and combined hypertension on left ventricular geometry and function: the LIFE Study. Am J Hypertens 2001, 14:768-74.
- [9]Heesen WF, Beltman FW, May JF, Smit AJ, de Graeff PA, Havinga TK, Schuurman FH, van der Veur E, Hamer JP, Meyboom-de Jong B, Lie KI: High prevalence of concentric remodeling in elderly individuals with isolated systolic hypertension from a population survey. Hypertension 1997, 29:539-43.
- [10]Ganau A, Devereux RB, Roman MJ, de Simone G, Pickering TG, Saba PS, Vargiu P, Simongini I, Laragh JH: Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol 1992, 19:1559-60.
- [11]Andrén Bertil, Lind Lars, Hedenstierna Göran, Lithell Hans: Left Ventricular Systolic Function in a Population Sample of Elderly Men. European Heart Journal 1996, 17:1800-1807.
- [12]Sundström Johan, Lind Lars, Ärnlöv Johan, Zethelius Björn, Andrén Bertil, Hans LithellO: Echocardiographic and Electrocardiographic Diagnoses of Left Ventricular Hypertrophy Predict Mortality Independently of Each Other in a Population of Elderly Men. Circulation 2001, 103:2346-2351.
- [13]Sundström J, Ärnlöv J, Stolare K, Lind L: Diabetes, lipids and metabolism: Blood pressure-independent relations of left ventricular geometry to the metabolic syndrome and insulin resistance: a population-based study. Heart 2008, 94:874-878.
- [14]Krumholz HM, Larson M, Levy D: Sex-differences in cardiac adaptation to isolated systolic hypertension. American journal of Cardiology 1993, 72:310-313.
- [15]Dahlöf B, Devereux R, de Faire U, Fyhrquist F, Hedner T, Ibsen H, Julius S, Kjeldsen S, Kristianson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H: The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study: rationale, design, and methods. The LIFE Study Group. Am J Hypertens 1997, 10:705-13.
- [16]Harlan KrumolzM, Larson Martin, Levy Daniel: Prognosis of Left Ventricular Geometric Patterns in the Framingham Heart Study. J Am Coll Cardiol 1995, 25(4):879-84.
- [17]Kuch B, Muscholl M, Luchner A, Döring A, Riegger GAJ, Schunkert H, Hense H-W: Gender specific differences in left ventricular adaptation to obesity and hypertension. Journal of Human Hypertension 1998, 12:695-691.
- [18]Sveälv BG, Fritzon Gunilla, Andersson Bert: Gender and age related differences in left ventricular function and geometry with focus on the long axis. Eur J Echo 2006, 7:298-307.