Prevalence of congenital heart defect in Guangdong province, 2008-2012

BMC Public Health

Qingguo Zhao²  Youjie Wang¹  Yuntao Wu²  Shiyun Li²  Yuanzhu Ma²  Zhijiang Liang²  Cunwei Ji²  Jianhong Xia²  Bing Li²  Li Wu² 

[1] Department of Maternal and Child health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Guangdong Women and Children Hospital, Guangzhou, China

关键词: Prevalence;    Congenital heart defect;    Birth defects;   

Others  :  1145355
DOI  :  10.1186/1471-2458-14-152

 received in 2013-07-14, accepted in 2014-02-10,  发布年份 2014

【 摘 要 】

Background

Congenital heart defect (CHD) is the most common major malformations in infants. Little is known about the main epidemiologic characteristics of CHD prevalence in Guangdong province, China. Our study was undertaken to investigate the time trends in the prevalence of CHD in Guangdong province from 2008 to 2012.

Methods

Data were retrieved from the Guangdong Hospital-Based Birth Defects Monitoring System during 2008–2012. All infants more than 28 weeks of gestation and infants up to 7 days of age in monitoring hospitals were monitored. We used prevalence rate to describe the difference in prevalence of CHD between rural and urban areas. Odds ratio (OR) and 95% confidence interval (CI) for CHD were calculated for the rural and urban areas. The CHD rate was calculated on the basis of birth defects per 10,000 births.

Results

A total of 1005052 births were reported to the Birth Defects Monitoring Network of Guangdong Province, of which 5268 cases were diagnosed as CHD. The overall prevalence of CHD was 52.41 per 10 000 births (95% CI: 51.00 ~ 53.83) in provincial-wide, 66.08 per 10 000 births (95% CI: 63.77 ~ 68.39) in urban areas, and 40.23 per 10 000 births (95% CI: 38.52 ~ 41.93) in rural areas. The prevalence of CHD increased with maternal age both in urban areas (P < 0.01) and in rural areas (P < 0.01).

Conclusion

The increasing trends of CHD prevalence suggest that maternal age and the improvement of diagnosis ability might play a critical role.

【 授权许可】

   
2014 Wu et al.; licensee BioMed Central Ltd.

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