The impact of dialysis therapy on older patients with advanced chronic kidney disease: a nationwide population-based study

BMC Medicine

Der-Cherng Tarng³  Shu-Chen Kuo¹  Wu-Chang Yang²  Shuo-Ming Ou³  Yung-Tai Chen⁵  Chia-Jen Shih⁴ 

[1] Division of Infectious Diseases, Taipei Veterans General Hospital, Taipei, Taiwan;Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan;Institutes of Physiology and Clinical Medicine, National Yang-Ming University, Taipei, Taiwan;School of Medicine, National Yang-Ming University, Taipei, Taiwan;Department of Medicine, Taipei City Hospital Heping Fuyou Branch, Taipei, Taiwan

关键词: Older people;    Conservative care;    Dialysis;    Advanced chronic kidney disease;   

Others  :  1121414
DOI  :  10.1186/s12916-014-0169-3

 received in 2014-07-27, accepted in 2014-09-01,  发布年份 2014

【 摘 要 】

Background

Older patients with advanced chronic kidney disease (CKD) face the decision of whether to undergo dialysis. Currently available data on this issue are limited because they were generated by small, short-term studies with statistical drawbacks. Further research is urgently needed to provide objective information for dialysis decision making in older patients with advanced CKD.

Methods

This nationwide population-based cohort study was conducted using Taiwan’s National Health Insurance Research Database. Data from 2000 to 2010 were extracted. A total of 8,341 patients ≥70 years old with advanced CKD and serum creatinine levels >6 mg/dl, who had been treated with erythropoiesis-stimulating agents were included. Cox proportional hazard models in which initiation of chronic dialysis was defined as the time-dependent covariate were used to calculate adjusted hazard ratios for mortality. The endpoint was all-cause mortality.

Results

During a median follow-up period of 2.7 years, 6,292 (75.4%) older patients chose dialysis therapy and 2,049 (24.6%) received conservative care. Dialysis was initiated to treat kidney failure a median of 6.4 months after enrollment. Dialysis was associated with a 1.4-fold increased risk of mortality compared with conservative care (adjusted hazard ratio 1.39, 95% confidence interval 1.30 to 1.49). In subgroup analyses, the risk of mortality remained consistently increased, independent of age, sex and comorbidities.

Conclusions

In older patients, dialysis may be associated with increased mortality risk and healthcare cost compared with conservative care. For patients who are ≥70 years old with advanced CKD, decision making about whether to undergo dialysis should be weighted by consideration of risks and benefits.

【 授权许可】

   
2014 Shih et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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