Sensory response following knee joint damage in rabbits

BMC Musculoskeletal Disorders

David Diduch¹  MaCalus V Hogan¹  Luke Choi¹  Matthew Bessette¹  Joseph M Hart¹ 

[1] Department of Orthopaedic Surgery, University of Virginia, BOX 800159, Charlottesville, VA 22904, USA

关键词: Reconstruction;    Anterior cruciate ligament;    Afferent;    Femoral nerve;   

Others  :  1127696
DOI  :  10.1186/1471-2474-15-139

 received in 2013-05-27, accepted in 2014-04-10,  发布年份 2014

【 摘 要 】

Background

Altered sensory information arising from damaged knee joint structures has been hypothesized as a contributing factor to persistent muscle dysfunction following injury.

Methods

Composite femoral nerve sensory signal was measured in 24 rabbits randomly allocated (8 per group) to receive surgical anterior cruciate ligament (ACL) transection with or without autograft reconstruction or nothing (control). Two-weeks after the intervention composite afferent signals were recorded from the femoral nerve. Side-to-side ratios (surgical side vs contralateral healthy side) for peak femoral nerve afferent composite signal were used for comparison.

Results

Femoral nerve afferent signal ratios were significantly higher in the ACL-R (2.21 ± 0.74) group when compared to the ACL-T (1.28 ± 0.61, P = 0.02) group and Control group (1.31 ± 0.78, P = 0.03).

Conclusion

The magnitude of sensory information recorded on the femoral nerve is increased following ACL injury and reconstruction surgery, but not after an isolated ACL injury in rabbits.

【 授权许可】

   
2014 Hart et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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