Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy

BMC Cardiovascular Disorders

Nobukazu Ishizaka¹  Masaaki Hoshiga¹  Koichi Sohmiya¹  Yoshikatsu Okada²  Toshiyuki Ikemoto²  Kazushi Sakane¹  Takahide Ito¹  Shun Kizawa¹  Yoshihiro Takeda¹  Shu-ichi Fujita¹ 

[1] Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka 569-8686, Japan;Department of Central Clinical Laboratory, Osaka Medical College, Osaka, Japan

关键词: Antithrombotic drugs;    Cardiac function;    Left ventricular hypertrophy;    Platelet function;   

Others  :  1213970
DOI  :  10.1186/s12872-015-0047-8

 received in 2015-02-10, accepted in 2015-06-01,  发布年份 2015

【 摘 要 】

Background

Mean platelet volume (MPV) and platelet distribution width (PDW) are indices that reflect platelet activity. We investigated the association between these platelet indices and left ventricular hypertrophy and cardiac function.

Methods

We analyzed the data of 1241 patients who were admitted to the Cardiology Department.

Results

Both MPV and PDW were selected as independent factors associated with left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy. The highest tertile of MPV and PDW was associated with left ventricular systolic dysfunction (left ventricular ejection fraction of <50 %) with an odds ratio of 1.53 and 2.03, respectively, when the respective lowest tertile was used as reference. The highest PDW tertile was associated with left ventricular hypertrophy with an odds ratio of 1.56 (95 % CI, 1.13–2.15) and with dysfunction with an odds ratio of 3.34 (95 % CI, 1.54–7.25).

Conclusions

Indices of platelet activation (MPV and/or PDW) were independently associated positively with left ventricular hypertrophy and left ventricular systolic and diastolic dysfunction. Whether these platelet indices represent useful markers for identifying individuals at higher risk for thromboembolic disease and organ damage among cardiac patients awaits further investigation.

【 授权许可】

   
2015 Fujita et al.

【 图 表 】

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