Body fatness and breast cancer risk in women of African ancestry

BMC Cancer

Elisa V Bandera²  Urmila Chandran²  Gary Zirpoli¹  Zhihong Gong¹  Susan E McCann¹  Chi-Chen Hong¹  Gregory Ciupak¹  Karen Pawlish³  Christine B Ambrosone¹ 

[1] Department of Cancer Prevention & Control, Roswell Park Cancer Institute, Buffalo, NY, USA

[2] Rutgers School of Public Health, Piscataway, NJ, USA

[3] New Jersey State Cancer Registry, New Jersey Department of Health, Trenton, NJ, USA

关键词: African American;    Percent body fat;    Body composition;    Waist circumference;    Body fat distribution;    Body mass index;    Obesity;    Breast cancer;   

Others  :  1079517
DOI  :  10.1186/1471-2407-13-475

 received in 2013-02-26, accepted in 2013-10-12,  发布年份 2013

【 摘 要 】

Background

Obesity has been shown to be inversely associated with breast cancer risk in premenopausal women, while increasing risk in postmenopausal women. However, the current evidence is largely based on studies in Caucasian populations. Associations in women of African ancestry (AA), who have a higher prevalence of obesity, have been evaluated in few studies and results suggest different effects.

Methods

We evaluated the impact of body size, body fat distribution, and body composition on breast cancer risk among AA women (978 cases and 958 controls) participating in the Women’s Circle of Health Study, a multi-site case–control study in New York City (NYC) and New Jersey (NJ). Cases were newly diagnosed with histologically confirmed ductal carcinoma in situ or invasive breast cancer, age 20–75 yrs. In NYC, cases were recruited through hospitals with the largest referral patterns for AA women and controls through random digit dialing (RDD). In NJ, cases were identified in seven counties in NJ thorough the NJ State Cancer Registry, and controls through RDD and community-based recruitment. During in-person interviews, questionnaires were administered and detailed anthropometric measurements were obtained. Body composition was assessed by bioelectrical impedance analysis.

Results

BMI did not have a major impact on pre- or post-menopausal breast cancer, but was significantly associated with reduced risk of ER-/PR- tumors among postmenopausal women (OR: 0.37; 95% CI: 0.15-0.96 for BMI > 30 vs. BMI < 25). Furthermore, increased premenopausal breast cancer risk was found for higher waist and hip circumferences after adjusting for BMI, with ORs of 2.25 (95% CI: 1.07-4.74) and 2.91 (95% CI: 1.39-6.10), respectively, comparing the highest vs. lowest quartile. While ORs for higher fat mass and percent body fat among postmenopausal women were above one, confidence intervals included the null value.

Conclusions

Our study suggests that in AA women BMI is generally unrelated to breast cancer. However, higher waist and hip circumferences were associated with increased pre-menopausal breast cancer risk, while general obesity was associated with decreased risk of ER-/PR- tumors. Larger studies are needed to confirm findings and to evaluate the impact of obesity on breast cancer subtypes.

【 授权许可】

   
2013 Bandera et al.; licensee BioMed Central Ltd.

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