The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variants

BMC Medicine

Robert Zivadinov¹  Karen Marr¹  Yuval Karmon²  Adnan H Siddiqui²  Kresimir Dolic³ 

[1] Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, 100 High St., Buffalo, NY 14203, USA;Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, 100 High St., Buffalo, NY 14203, USA;Department of Radiology, University Hospital Center Split, University of Split, Spinciceva 1, Split 21000, Croatia

关键词: Multimodal Imaging;    Plethismography;    Intravascular Ultrasound;    Catheter Venography;    Computed Tomography Venography;    Magnetic Resonance Venography;    Doppler Sonography;    Jugular Vein Reflux;    CCSVI;    Multiple Sclerosis;   

Others  :  856975
DOI  :  10.1186/1741-7015-11-155

 received in 2013-02-14, accepted in 2013-05-30,  发布年份 2013

【 摘 要 】

The extra-cranial venous system is complex and not well studied in comparison to the peripheral venous system. A newly proposed vascular condition, named chronic cerebrospinal venous insufficiency (CCSVI), described initially in patients with multiple sclerosis (MS) has triggered intense interest in better understanding of the role of extra-cranial venous anomalies and developmental variants. So far, there is no established diagnostic imaging modality, non-invasive or invasive, that can serve as the “gold standard” for detection of these venous anomalies. However, consensus guidelines and standardized imaging protocols are emerging. Most likely, a multimodal imaging approach will ultimately be the most comprehensive means for screening, diagnostic and monitoring purposes. Further research is needed to determine the spectrum of extra-cranial venous pathology and to compare the imaging findings with pathological examinations. The ability to define and reliably detect noninvasively these anomalies is an essential step toward establishing their incidence and prevalence. The role for these anomalies in causing significant hemodynamic consequences for the intra-cranial venous drainage in MS patients and other neurologic disorders, and in aging, remains unproven.

【 授权许可】

   
2013 Dolic et al.; licensee BioMed Central Ltd.

【 图 表 】

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