Prehypertension and incidence of cardiovascular disease: a meta-analysis

BMC Medicine

Dingli Xu³  Hongfeng Tang²  Yunzhao Hu²  Weiyi Mai¹  Xiaoyan Cai²  Sheng Wang³  Yuli Huang³ 

[1] Department of Cardiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Clinical Medicine Research Center, the Affiliated Hospital at Shunde, Southern Medical University (the First People’s Hospital of Shunde), Foshan, China;Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, China

关键词: Meta-analysis;    Morbidity;    Cardiovascular diseases;    Prehypertension;   

Others  :  856946
DOI  :  10.1186/1741-7015-11-177

 received in 2013-04-05, accepted in 2013-06-27,  发布年份 2013

【 摘 要 】

Background

Prospective cohort studies of prehypertension and the incidence of cardiovascular disease (CVD) are controversial after adjusting for other cardiovascular risk factors. This meta-analysis evaluated the association between prehypertension and CVD morbidity.

Methods

Databases (PubMed, EMBASE and the Cochrane Library) and conference proceedings were searched for prospective cohort studies with data on prehypertension and cardiovascular morbidity. Two independent reviewers assessed the reports and extracted data. The relative risks (RRs) of CVD, coronary heart disease (CHD) and stroke morbidity were calculated and reported with 95% confidence intervals (95% CIs). Subgroup analyses were conducted on blood pressure, age, gender, ethnicity, follow-up duration, number of participants and study quality.

Results

Pooled data included the results from 468,561 participants from 18 prospective cohort studies. Prehypertension elevated the risks of CVD (RR = 1.55; 95% CI = 1.41 to 1.71); CHD (RR = 1.50; 95% CI = 1.30 to 1.74); and stroke (RR = 1.71; 95% CI = 1.55 to 1.89). In the subgroup analyses, even for low-range prehypertension, the risk of CVD was significantly higher than for optimal BP (RR = 1.46, 95% CI = 1.32 to 1.62), and further increased with high-range prehypertension (RR = 1.80, 95% CI = 1.41 to 2.31). The relative risk was significantly higher in the high-range prehypertensive populations than in the low-range populations (χ²= 5.69, P = 0.02). There were no significant differences among the other subgroup analyses (P>0.05).

Conclusions

Prehypertension, even in the low range, elevates the risk of CVD after adjusting for multiple cardiovascular risk factors.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

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