Restless legs syndrome and quality of sleep in patients with glomerulopathy

BMC Nephrology

Veralice Meireles Sales de Bruin³  Luiza de Andrade Braga Farias¹  Cecília Alencar de Diógenes²  Natália Feitosa Arraes Minete²  João Paulo Lima Santos²  Alexandre Braga Libório⁴ 

[1] Post-graduate Program, Universidade de Fortaleza, Fortaleza, Ceará, Brazil;Medical Course, Universidade de Fortaleza, Fortaleza, Ceará, Brazil;Department of Clinical Medicine – Faculdade de Medicina, Universidade Federal do Ceará, Avenida Abolição no. 4043 Ap. 1203 Edifício Jangada, Mucuripe, CEP 60.165-082, Fortaleza, Ceará, Brazil;Nephrology Department, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil

关键词: Proteinuria;    Nephrotic syndrome;    Sleep quality;   

Others  :  1082926
DOI  :  10.1186/1471-2369-14-113

 received in 2013-01-28, accepted in 2013-05-21,  发布年份 2013

【 摘 要 】

Background

Despite a confirmed association between restless legs syndrome (RLS) and end-stage renal disease (ESRD), there is no study on patients presenting with nephrotic syndrome (NS). To investigate the frequency of RLS and poor quality sleep in NS-patients secondary to primary glomerulopathy with nearly normal glomerular filtration rate (GFR) and its associated factors.

Methods

Patients with NS, defined as 24 h-urine protein greater than 3.5 g/1.73 m² and hypoalbuminemia, (n = 99, 53 women) and a mean age of 36±11 years were studied. Age and sex-matched controls were used to compare RLS and poor sleep quality prevalence. Standardized RLS questionnaire formulated by the International Restless Legs Syndrome and Pittsburgh Sleep Quality Index (PSQI) were used.

Results

RLS was more frequent in NS-patients than in controls (22.8 vs. 4.0%, p = 0.01). Mean time since diagnosis (52.2±34.1 vs. 28.6±22.5 months, p < 0.01) and 24 h-proteinuria (3.7±1.3 vs. 2.6±0.6 g/1.73 m², p = 0.001) were greater in NS-patients with RLS those not presenting RLS. Association between RLS with 24 h-proteinuria [OR = 2.31; p = 0.007; 95% CI 1.87-2.89] and time since diagnosis [OR = 1.10; p = 0.003; CI = 1.02-1.39] were identified even after controlling for age, GFR and diabetes. Sleep quality was poor in NS-patients than in controls (mean PSQI score 7.35±3.7 vs. 5.2±3.0, p = 0.003). In NS-patients, only RLS was associated with poor sleep quality (OR = 1.20; p = 0.004).

Conclusion

Poor quality sleep and RLS are frequent in NS-patients without ESRD. Pathophysiology of this association must be further investigated.

【 授权许可】

   
2013 Libório et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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