Maximal exercise in obese patients with COPD: the role of fat free mass

BMC Pulmonary Medicine

Alfredo Chetta¹  Emilio Marangio¹  Maria Rosaria Gioia¹  Sara Ramponi¹  Panagiota Tzani¹  Elisabetta Teopompi¹  Marina Aiello¹ 

[1] Dept of Clinical & Experimental Medicine, Respiratory Disease and Lung Function Unit, University of Parma, Strada dell’Università 12, Parma 43100, Italy

关键词: COPD;    Obesity;    Exercise;    Dynamic hyperinflation;    Fat-free mass;   

Others  :  862826
DOI  :  10.1186/1471-2466-14-96

 received in 2014-02-27, accepted in 2014-05-21,  发布年份 2014

【 摘 要 】

Background

Obese patients (OB) with COPD may better tolerate exercise as compared to normal weight (NW) COPD patients, even if the reason for this is not yet fully understood. We investigated the interactions between obesity, lung hyperinflation, fat-free mass (FFM) and exercise capacity in COPD.

Methods

Forty-four patients (16 females; age 65 ± 8 yrs) were assessed by resting lung function and body composition and exercised on a cycle-ergometer to exhaustion.

Results

Twenty-two OB and 22 NW patients did not differ in age, gender and airflow obstruction degree, but in FFM (p < 0.05). OB had significantly higher values in inspiratory capacity/total lung capacity ratio (IC/TLC) at rest (p < 0.01), but not at peak of exercise and showed significantly higher values in peak workload (p < 0.05) and in peak oxygen uptake (VO₂), when expressed as absolute value (p < 0.05), but not when corrected by FFM. OB compared to NW experienced lower leg fatigue (p < 0.05), but similar dyspnea on exertion. In all patients, the regression equation by stepwise multiple regression analysis for peak workload and VO₂, as dependent variables included both FFM and IC/TLC at rest, as independent variables (r² = 0.43 and 0.37, respectively).

Conclusions

OB with COPD, as compared to NW patients matched for age, gender and airflow obstruction, had greater FFM and less resting lung hyperinflation and showed greater maximal exercise capacity. Pulmonary and non-pulmonary factors may explain the preservation of exercise tolerance in patients with COPD associated with obesity.

【 授权许可】

   
2014 Aiello et al.; licensee BioMed Central Ltd.

【 图 表 】

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