Gender differences in first episode psychotic mania

BMC Psychiatry

Philippe Conus⁵  Patrick D McGorry³  Felicity J Butselaar³  Benno G Schimmelmann²  Michael Berk⁴  Martin Lambert¹  Sue M Cotton³ 

[1] Psychosis Early Detection and Intervention Centre (PEDIC), Department for Psychiatry and Psychotherapy, Centre for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;University Hospital of Child and Adolescent Psychiatry, University of Bern, Bern, Switzerland;Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia;Florey Institute for Neuroscience and Mental Health, Parkville, Australia;Treatment and Early Intervention in Psychosis Program (TIPP), Département de Psychiatrie CHUV, Université de Lausanne, Clinique de Cery, Prilly, Switzerland

关键词: Bipolar disorder;    Psychosis;    Mania;    Gender;   

Others  :  1124111
DOI  :  10.1186/1471-244X-13-82

 received in 2013-01-23, accepted in 2013-01-28,  发布年份 2013

【 摘 要 】

Background

The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients.

Methods

Medical file audit assessment of 118 (male = 71; female = 47) patients with FEPM aged 15 to 29 years was undertaken on clinical and functional measures.

Results

Males with FEPM had increased likelihood of substance use (OR = 13.41, p < .001) and forensic issues (OR = 4.71, p = .008), whereas females were more likely to have history of sexual abuse trauma (OR = 7.12, p = .001). At service entry, males were more likely to be using substances, especially cannabis (OR = 2.15, p = .047), had more severe illness (OR = 1.72, p = .037), and poorer functioning (OR = 0.96, p = .045). During treatment males were more likely to decrease substance use (OR = 5.34, p = .008) and were more likely to be living with family (OR = 4.30, p = .009). There were no gender differences in age of onset, psychopathology or functioning at discharge.

Conclusions

Clinically meaningful gender differences in FEPM were driven by risk factors possibly associated with poor outcome. For males, substance use might be associated with poorer clinical presentation and functioning. In females with FEPM, the impact of sexual trauma on illness course warrants further consideration.

【 授权许可】

   
2013 Cotton et al.; licensee BioMed Central Ltd.

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